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IL-33

IL-33 Overview

English Name	Interleukin-33	Approved Drugs	0
Drugs in Clinical Trials	9	Target Synonym	Nuclear Factor For High Endothelial Venules，DVS27-Related Protein，IL1F11，IL33，Interleukin-1 family member 11，IL-1F11，Interleukin 33，Nuclear Factor From High Endothelial Venules，C9orf26，NF-HEV，Chromosome 9 Open Reading Frame 26 (NF-HEV)，Interleukin-1 Family， Member 11，NFEHEV，DVS27，IL-33，NFHEV，Interleukin-33，DKFZp586H0523
Highest Development Stage	Phase 3 Clinical

English Name	Interleukin-33
Target Synonym	Nuclear Factor For High Endothelial Venules，DVS27-Related Protein，IL1F11，IL33，Interleukin-1 family member 11，IL-1F11，Interleukin 33，Nuclear Factor From High Endothelial Venules，C9orf26，NF-HEV，Chromosome 9 Open Reading Frame 26 (NF-HEV)，Interleukin-1 Family， Member 11，NFEHEV，DVS27，IL-33，NFHEV，Interleukin-33，DKFZp586H0523
Approved Drugs	0
Drugs in Clinical Trials	9
Highest Development Stage	Phase 3 Clinical

IL-33 Product List

Product Category
Protein (12)
Product Status
Launched (12)
Species
Human (7)Cynomolgus (3)Mouse (2)
Tag
His Tag (7)His Tag & Avi Tag (5)
Conjugate
Unconjugated (7)Biotin-labeled (5)

Cat. No.	Species	Host	Product Description
HOT IL3-H52H6	Human	HEK293	Human IL-33 (C208S, C227S, C232S, C259S) Protein, His Tag, low endotoxin (MALS verified)
HOT IL3-H52H7	Human	HEK293	Human IL-33 Protein, His Tag (HPLC verified)
HOT IL3-H82H5	Human	HEK293	Biotinylated Human IL-33 Protein, His,Avitag™ (MALS verified)
HOT IL3-C5245	Cynomolgus	HEK293	Cynomolgus IL-33 Protein, His Tag (MALS verified)
IL3-H51H3	Human	E. coli	Human IL-33 (2-270) Protein, His Tag
IL3-H52H8	Human	HEK293	Human IL-33 (C208S, C259S) Protein, His Tag (MALS verified)
IL3-H82E6	Human	HEK293	Biotinylated Human IL-33 (C208S, C259S) Protein, His,Avitag™ (HPLC verified)
IL3-H82E7	Human	HEK293	Biotinylated Human IL-33 (C208S, C227S, C232S, C259S) Protein, His,Avitag™ (MALS verified)
IL3-M5245	Mouse	HEK293	Mouse IL-33 Protein, His Tag
IL3-M82Q7	Mouse	HEK293	Biotinylated Mouse IL-33 Protein, His,Avitag™ (MALS verified)

Total: 12

IL-33 Background

Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.

IL-33 Synonyms

IL33,DV27,C9ORF26,IL1F11,NFHEV,DKFZp586H0523,DVS27,NFEHEV,RP11-575C20.2

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Tozorakimab	MEDI-3506	Phase 3 Clinical	Medimmune	Asthma; Bronchitis, Chronic; Dermatitis, Atopic; Diabetic Nephropathies; Pneumonia, Viral; Pulmonary Disease, Chronic Obstructive	Details
Itepekimab	REGN-3500; SAR-440340	Phase 3 Clinical	Regeneron Pharmaceuticals Inc, Sanofi	Asthma; Bronchiectasis; Chronic rhinosinusitis with nasal polyps (CRSwNP); Dermatitis, Atopic; Nasal Polyps; Pulmonary Disease, Chronic Obstructive; Sinusitis	Details
Etokimab	ANB-020	Phase 2 Clinical	Anaptysbio Inc	Asthma; Dermatitis, Atopic; Hypersensitivity; Peanut Hypersensitivity; Pulmonary Eosinophilia; Sinusitis	Details
MT-2990	MT-2990	Phase 2 Clinical	Mitsubishi Tanabe Pharma Corp	Endometriosis; Pain; Rhinitis, Allergic, Seasonal; Vasculitis	Details
GSK-3862995	GSK-3862995B; GSK3862995; GSK-3862995; GSK3862995B	Phase 2 Clinical	Glaxosmithkline Plc	Bronchiectasis; Pulmonary Disease, Chronic Obstructive	Details
Ompekimig	PF-07264660	Phase 2 Clinical	Pfizer Inc	Dermatitis, Atopic	Details
SSGJ-621	SSGJ-621; 621	Phase 1 Clinical	Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd	Asthma; Pulmonary Disease, Chronic Obstructive	Details
CAN-10	CAN-10	Phase 1 Clinical	Lund University Foundation	Myocarditis; Plaque psoriasis; Scleroderma, Systemic	Details
QX-007N	QX-007N	Phase 1 Clinical	Qyuns Therapeutics Co Ltd	Asthma; Pulmonary Disease, Chronic Obstructive	Details

Product Reviews

1***62019-09-26
1People Like
Human IL-33 Protein, His Tag (HPLC verified)
I used this protein to explore and establish experimental methods to do antibody screening. The experimental methods that I used include Elisa, flow cytometry, octet determination of antibody binding and competition experiments. The protein works well, the experiments results met my expectations. I buy ACRO's protein frequently.