IL-17 RA Molekülinformation
Molecule Name
Interleukin-17 receptor A
Molekülalias
CD217,CDw217,IL-17RA,IL17R,CANDF5,hIL-17R
Drug Development Progress
Anzahl der klinischen Arzneimittel2
Anzahl der inverkehr gebrachten Arzneimittel1
Höchste Forschungs- und EntwicklungsphaseApproved
Target-Alias
CDw217，IL-17 receptor A，IL17R，IL17RA，Interleukin 17 Receptor A，IL-17RA，Interleukin 17 Receptor，CD217 Antigen，HIL-17R，CANDF5，CD217，IMD51，Interleukin-17 receptor A
Molekülhintergrund
Interleukin 17 receptor A (IL17RA) is also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes, belong to ubiquitous type I membrane glycoprotein, and binds with low affinity to interleukin 17A (IL17A). IL 17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested . IL 17RA associates with IL 17RC to form a signaling receptor complex for IL 17 and IL 17F . Ligand and IL 17RA ligation promotes T cell activation and the production of IL - 6, G-CSF, SCF, and multiple pro-inflammatory chemokines. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5).
IL-17 RA Produktliste
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Klinische Arzneimittelinformation
| Englischer Name | Forschungscode | Forschungsphase | Firma | Indikationen | Klinische Studie |
|---|---|---|---|---|---|
| XCUR-17 | XCUR-17 | Phase 1 Clinical | Exicure Inc | Psoriasis | Details |
| PN-881 | PN-881 | Phase 1 Clinical | Protagonist Therapeutics Inc | Dermatitis; Psoriasis | Details |
Inverkehr gebrachte Arzneimittelinformation
| Englischer Name | Forschungscode | Forschungsphase | Firma | Frühestes Markenname | Frühestes Genehmigungsland | Früheste Indikation | Früheste Genehmigungsgesellschaft | Früheste Genehmigungsdatum | Indikationen | Klinische Studie |
|---|---|---|---|---|---|---|---|---|---|---|
| Brodalumab | AMG-827; KHK-4827; IL-17R mAb; MEDI-6365 | Approved | Amgen Inc | Siliq, Lumicef, Kyntheum, 立美芙 | Japan | Psoriasis; Arthritis, Psoriatic | Kyowa Kirin Co Ltd | 2016-07-04 | Arthritis, Psoriatic; Arthritis, Rheumatoid; Asthma; Axial Spondyloarthritis; Brain Neoplasms; Breast Neoplasms; Colonic Neoplasms; Crohn Disease; Esophageal Neoplasms; Genital Neoplasms, Female; Head and Neck Neoplasms; Hidradenitis Suppurativa; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Mouth Neoplasms; Non-radiographic axial spondyloarthritis; Palmoplantar pustulosis; Pancreatic Neoplasms; Plaque psoriasis; Prostatic Neoplasms; Psoriasis; Pustular psoriasis; Rectal Neoplasms; Scleroderma, Systemic; Skin Neoplasms; Solid tumours; Spondylitis, Ankylosing; Stomach Neoplasms; Testicular Neoplasms; Thyroid Neoplasms | Details |