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Mouse IL-17 RA / CD217 Protein, His Tag (MALS verified)

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Product Number/Spec
Price
Menge
ILA-M52H6-100ug
$315.00
ILA-M52H6-1mg (500ug X 2)
$2165.00
ETA of in-stock products:2 business days
Gesamtanzahl Product Amount$ 0

Product Details

  • Synonyms

    CD217, CDw217, IL-17RA, IL17R, CANDF5, hIL-17R

  • Source

    Mouse IL-17 RA Protein, His Tag (ILA-M52H6) is expressed from human 293 cells (HEK293). It contains AA Ser 32 - Trp 322 (Accession # Q60943).

    Predicted N-terminus: Ser 32

    Request for sequence
  • Molecular Characterization

    IL-17 RA Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 35.2 kDa. The protein migrates as 53-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Data Display

  • SDS-PAGE

    IL-17 RA SDS-PAGE

    Mouse IL-17 RA Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    IL-17 RA SEC-MALS

    The purity of Mouse IL-17 RA Protein, His Tag (Cat. No. ILA-M52H6) is more than 95% and the molecular weight of this protein is around 50-65 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     IL-17 RA ELISA

    Immobilized Mouse IL-17 RA Protein, His Tag (Cat. No. ILA-M52H6) at 5 μg/mL (100 μL/well) can bind Biotinylated Mouse IL-17A Protein, His,Avitag (Cat. No. ILA-M82Q3) with a linear range of 0.03-5 ng/mL (QC tested).

    Protocol

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Publish Comment

Background Introduction

Interleukin 17 receptor A (IL17RA) is also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes, belong to ubiquitous type I membrane glycoprotein, and binds with low affinity to interleukin 17A (IL17A). IL 17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested . IL 17RA associates with IL 17RC to form a signaling receptor complex for IL 17 and IL 17F . Ligand and IL 17RA ligation promotes T cell activation and the production of IL - 6, G-CSF, SCF, and multiple pro-inflammatory chemokines. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5).

Frontier Progress

 
Drug Development Progress
  • English Name:

    Interleukin-17 receptor A

  • Category:

  • Listed Drugs Count:

    1 Details

  • Clinical Drugs Count:

    2 Details

  • Highest R&D Stage:

    Approved

Drug Candidate Licensing
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