Biotinylated Mouse TROP-2 / TACSTD2 Protein, Fc,Avitag™ (MALS verified)

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Cat. No. / Size
Price
Qty
TR2-M82F3-25ug
$380.00
TR2-M82F3-200ug
$1495.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    TACSTD2, GA733-1, M1S1, TROP2

  • Source

    Biotinylated Mouse TROP-2 Protein, Fc,Avitag (TR2-M82F3) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Gly 270 (Accession # Q8BGV3-1).

    Predicted N-terminus: Gln 25

    Request for sequence
  • Molecular Characterization

    TROP-2 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 56.1 kDa. The protein migrates as 75-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Labeling

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • Protein Ratio

    Passed as determined by the HABA assay / binding ELISA.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    TROP-2 SDS-PAGE

    Biotinylated Mouse TROP-2 Protein, Fc,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    TROP-2 SEC-MALS

    The purity of Biotinylated Mouse TROP-2 Protein, Fc,Avitag (Cat. No. TR2-M82F3) is more than 90% and the molecular weight of this protein is around 120-145 kDa verified by SEC-MALS.

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Background

TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.

Recent Advances

 
Drug Development Progress
  • English Name:

    Tumor-associated calcium signal transducer 2

  • Category:

  • Approved Drugs:

    3 Details

  • Drugs in Clinical Trials:

    47 Details

  • Highest Development Stage:

    Approved

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