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Biotinylated Mouse PTK7 / CCK4 Protein, His,Avitag™ (MALS verified)

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Product Number/Spec
Price
Menge
PT7-M82E3-25ug
$370.00
PT7-M82E3-200ug
$1465.00
ETA of in-stock products:2 business days
Gesamtanzahl Product Amount$ 0

Product Details

  • Synonyms

    PTK7, CCK4, CCK-4, Tyrosine-protein kinase-like 7, Protein-tyrosine kinase 7, Protein-tyrosine kinase 7

  • Source

    Biotinylated Mouse PTK7 Protein, His,Avitag (PT7-M82E3) is expressed from human 293 cells (HEK293). It contains AA Ala 23 - Thr 696 (Accession # Q8BKG3-1).

    Predicted N-terminus: Ala 23

    Request for sequence
  • Molecular Characterization

    PTK7 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 78.2 kDa. The protein migrates as 85-100 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Labeling

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • Protein Ratio

    Passed as determined by the HABA assay / binding ELISA.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Data Display

  • SDS-PAGE

    PTK7 SDS-PAGE

    Biotinylated Mouse PTK7 Protein, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    PTK7 SEC-MALS

    The purity of Biotinylated Mouse PTK7 Protein, His,Avitag (Cat. No. PT7-M82E3) is more than 90% and the molecular weight of this protein is around 80-105 kDa verified by SEC-MALS.

    Report

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Publish Comment

Background Introduction

PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

Frontier Progress

 
Drug Development Progress
  • English Name:

    Protein-tyrosine kinase 7

  • Category:

  • Listed Drugs Count:

    0 Details

  • Clinical Drugs Count:

    8 Details

  • Highest R&D Stage:

    Phase 2 Clinical

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