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Biotinylated Cynomolgus NKp46 / NCR1 / CD335 Protein, His,Avitag™ (MALS verified)

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Product Number/Spec
Price
Menge
NC1-C82E5-25ug
$360.00
NC1-C82E5-200ug
$1565.00
ETA of in-stock products:2 business days
Gesamtanzahl Product Amount$ 0

Product Details

  • Synonyms

    NCR1, LY94, CD335, NK-p46, hNKp46

  • Source

    Biotinylated Cynomolgus NKp46, His,Avitag (NC1-C82E5) is expressed from human 293 cells (HEK293). It contains AA Pro 22 - Arg 257 (Accession # Q95JB9-1).

    Predicted N-terminus: Pro 22

    Request for sequence
  • Molecular Characterization

    NKp46 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™).

    The protein has a calculated MW of 30.3 kDa. The protein migrates as 35-43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Labeling

    Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

  • Protein Ratio

    Passed as determined by the HABA assay / binding ELISA.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Data Display

  • SDS-PAGE

    NKp46 SDS-PAGE

    Biotinylated Cynomolgus NKp46, His,Avitag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    NKp46 SEC-MALS

    The purity of Biotinylated Cynomolgus NKp46, His,Avitag (Cat. No. NC1-C82E5) is more than 85% and the molecular weight of this protein is around 35-45 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     NKp46 ELISA

    Immobilized Biotinylated Cynomolgus NKp46, His,Avitag (Cat. No. NC1-C82E5) at 1 μg/mL (100 μL/well) on streptavidin (STN-N5116) precoated (0.5 μg/well) plate can bind Monoclonal Anti-NKp46 Antibody, Human IgG1 with a linear range of 0.1-1 ng/mL (QC tested).

    Protocol

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Publish Comment

Background Introduction

Natural cytotoxicity triggering receptor 1 (NCR1) is also known as Natural killer cell p46-related protein (NK-p46), Lymphocyte antigen 94 homolog (LY94), CD antigen CD335, which belongs to the natural cytotoxicity receptor (NCR) family. NCR1 contains two Ig-like (immunoglobulin-like) domains. NCR1 interacts with CD247 and FCER1G. NCR1 / CD335 may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Frontier Progress

 
Drug Development Progress
  • English Name:

    Natural cytotoxicity triggering receptor 1

  • Category:

  • Listed Drugs Count:

    0 Details

  • Clinical Drugs Count:

    3 Details

  • Highest R&D Stage:

    Phase 2 Clinical

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