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Biotinylated Human ENPP1 Protein, His,Avitag™ (active enzyme)

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EN1-H82Q3-25ug
$367.00
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EN1-H82Q3-200ug
$1,449.00
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EN1-H82Q3
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

ENPP1

Source

Biotinylated Human ENPP1 Protein, His,Avitag (EN1-H82Q3) is expressed from human 293 cells (HEK293). It contains AA Lys 98 - Asp 925 (Accession # P22413).

Predicted N-terminus: His

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the N-terminus, followed by an Avi tag (Avitag™).

The protein has a calculated MW of 98.7 kDa. The protein migrates as 95-130 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Labeling

Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

Protein Ratio

Passed as determined by the SABA assay / HABA assay / binding ELISA.

Purity

>90% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) is a membrane‑bound glycoprotein that regulates extracellular nucleotide metabolism. It hydrolyzes ATP to AMP and pyrophosphate, thereby controlling mineralization processes and signaling pathways. ENPP1 plays a critical role in bone and cartilage development, insulin signaling, and vascular calcification. Mutations in ENPP1 are linked to rare genetic disorders such as generalized arterial calcification of infancy and autosomal recessive hypophosphatemic rickets. Because of its dual involvement in skeletal biology and metabolic regulation, ENPP1 has become an important target for both diagnostic research and therapeutic development.