TPBG

TPBG Molekülinformation

Englischer Name	Trophoblast glycoprotein	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	16	Target-Alias	Trophoblast glycoprotein，5T4 oncotrophoblast glycoprotein，5T4，TPBG，5T4 oncofetal antigen，M6P1，5T4 oncofetal trophoblast glycoprotein，Wnt-Activated Inhibitory Factor 1，WAIF1，5T4AG，5T4-AG
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	Trophoblast glycoprotein
Target-Alias	Trophoblast glycoprotein，5T4 oncotrophoblast glycoprotein，5T4，TPBG，5T4 oncofetal antigen，M6P1，5T4 oncofetal trophoblast glycoprotein，Wnt-Activated Inhibitory Factor 1，WAIF1，5T4AG，5T4-AG
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	16
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

TPBG Produktliste

Attribut
Protein (9)Cell (1)Antibody (1)
Produktbibliothek
Online (10)In Forschung (1)
Spezies
Human (6)Cynomolgus / Rhesus macaque (1)Mouse (2)Rat (1)Rabbit (1)
Etikett
His Tag & Avi Tag (2)Fc Tag (2)His Tag (4)Fc Tag & Avi Tag (1)- (2)
Marker
Biotin-labeled (2)Unconjugated (8)- (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT TPG-H52E5	Human	HEK293	Unconjugated Human TPBG / 5T4 Protein, His,Avitag™ (MALS verified)	In den Warenkorb legen
HOT TPG-H82Eb	Human	HEK293	Biotinylated Human TPBG / 5T4 Protein, His,Avitag™	In den Warenkorb legen
HOT TPG-M52H3	Mouse	HEK293	Mouse TPBG / 5T4 Protein, His Tag (MALS verified)	In den Warenkorb legen
HOT TPG-C52H3	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque TPBG / 5T4 Protein, His Tag	In den Warenkorb legen
CHEK-ATP176	Human	HEK293	HEK293/Human TPBG Stable Cell Line	In den Warenkorb legen
TPG-H5253	Human	HEK293	Human TPBG / 5T4 Protein, Fc Tag (MALS verified)	In den Warenkorb legen
TPG-H52H3	Human	HEK293	Human TPBG / 5T4 Protein, His Tag (MALS verified)	In den Warenkorb legen
TPG-H82F6	Human	HEK293	Biotinylated Human TPBG / 5T4 protein, Fc,Avitag™ (MALS verified)	In den Warenkorb legen
TPG-M5255	Mouse	HEK293	Mouse TPBG / 5T4 Protein, Fc Tag (MALS verified)	In den Warenkorb legen
HGS-M2717	Rabbit	-	Recombinant Monoclonal Anti-TPBG Antibody, Rabbit (P1B10)	Vorbestellung

Gesamtmenge11

TPBG Molekülhintergrund

Trophoblast glycoprotein (TPBG), also known as 5T4, is the therapeutic target of several anticancer agents currently in clinical development, largely due to its high expression in tumors and low expression in normal adult tissues.This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. TPBG is expressed by all types of trophoblasts as early as 9 weeks of development.

TPBG Molekülalias

TPBG,5T4,M6P1,5T4AG,WAIF1,5T4 oncofetal antigen,Trophoblast glycoprotein,5T4 oncofetal trophoblast glycoprotein

Antikörperprojekt-Handelsplattform

Projektname	Projektphase	Molekültyp	Molekülquelle	Krankheitsgebiet	Indikationen
5T4 mAb - 01	Lead	Monoclonal	Humanized Mouse	Solid Tumor	Ovarian cancer,Lung cancer

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Naptumomab estafenatox	TTS-CD3; ABR-217620	Phase 2 Clinical	Active Biotech Ab	Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colorectal Neoplasms; Endometrial Neoplasms; Esophageal Neoplasms; Melanoma; Mesothelioma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms	Details
ALG.APV-527	ALG.APV 527; ADC-1016; ATOR-1016; ALG.APV-527; ALG-APV-527	Phase 2 Clinical	Alligator Bioscience Ab, Aptevo Therapeutics Inc	Neoplasms; Solid tumours	Details
JK-06	JK-06	Phase 2 Clinical	Xinlitai (Chengdu) Biological Technology Co Ltd	Neoplasms; Solid tumours	Details
TUB-030	TUB-030	Phase 2 Clinical	Tubulis GmbH	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms	Details
ACR-246	ACR246; ACR-246; ADC2154; ADC-2154	Phase 2 Clinical	Hangzhou Adcoris Biopharmacy Co Ltd	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Esophageal Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Solid tumours; Uterine Cervical Neoplasms	Details
IBR-854	IBR854; IBR-854	Phase 2 Clinical	Imbioray (Hangzhou) Biomedicine Co Ltd	Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Solid tumours	Details
SYD-1875	SYD-1875	Phase 1 Clinical	Synthon Bv	Solid tumours	Details
ASN-004	ASN-004	Phase 1 Clinical	Asana Biosciences Llc	Solid tumours	Details
anti-5T4 CAR NK-cell therapy (Wuxi Peapole's Hospital/Hangzhou Yingbairui Biomedical Technology)		Phase 1 Clinical	Imbioray (Hangzhou) Biomedicine Co Ltd	Solid tumours	Details
Naptumomab estafenatox/Durvalumab	NTX-352	Phase 1 Clinical	Neotx Therapeutics Ltd	Solid tumours	Details
XB-010	XB-010	Phase 1 Clinical	Exelixis Inc	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Esophageal Squamous Cell Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Triple Negative Breast Neoplasms	Details
FTL-008.16	FTL-008.16; FTL008.16	Phase 1 Clinical	Sound(Chengdu)Biopharmacauticals Co Ltd	Solid tumours	Details
CBA-1535	CBA-1535	Phase 1 Clinical	Chiome Bioscience Inc	Carcinoma, Non-Small-Cell Lung; Mesothelioma; Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Triple Negative Breast Neoplasms	Details
Anti-5T4 CAR-raNK Cell Therapy		Phase 1 Clinical	Imbioray (Hangzhou) Biomedicine Co Ltd	Solid tumours	Details
Prostate cancer vaccine(inactivated viral)(University of Oxford)		Clinical	University Of Oxford	Prostatic Neoplasms	Details
68Ga-NOTA-H006		Clinical	Huashan Hospital	Solid tumours	Details