Prolactin R
Prolactin R Molekülinformation
| Englischer Name | Prolactin receptor | Anzahl der inverkehr gebrachten Arzneimittel | 0 |
| Anzahl der klinischen Arzneimittel | 2 | Target-Alias | PRL-R，PRLR，Prolactin Receptor，Secreted Prolactin Binding Protein，HPRL Receptor，RI-PRLR，HPRLrI，HPRL，MFAB，Receptors， Prolactin |
| Höchste Forschungs- und Entwicklungsphase | Phase 3 Clinical | ||
| Englischer Name | Prolactin receptor |
| Target-Alias | PRL-R，PRLR，Prolactin Receptor，Secreted Prolactin Binding Protein，HPRL Receptor，RI-PRLR，HPRLrI，HPRL，MFAB，Receptors， Prolactin |
| Anzahl der inverkehr gebrachten Arzneimittel | 0 |
| Anzahl der klinischen Arzneimittel | 2 |
| Höchste Forschungs- und Entwicklungsphase | Phase 3 Clinical |
Prolactin R Produktliste
- Attribut
Protein (7)
- Produktbibliothek
Online (7)
- Spezies
Human (4)Cynomolgus (1)Rat (1)Mouse (1)
- Etikett
Fc Tag (1)His Tag (5)His Tag & Avi Tag (1)
- Marker
Unconjugated (6)Biotin-labeled (1)
| Produktnummer | Spezies | Expressionssystem | Produktbeschreibung | Proteinstruktur | Reinheit | Eigenschaften | Vorbestellen/Bestellen |
|---|---|---|---|---|---|---|---|
 Human | HEK293 | Human Prolactin R / PRLR Protein, Fc Tag |  |  |  |  In den Warenkorb legen | |
| Human | HEK293 | Human Prolactin R / PRLR Protein, His Tag&Tag Free, low endotoxin (MALS verified) | | | In den Warenkorb legen | ||
| Human | HEK293 | Human Prolactin R / PRLR Protein, His Tag |  | | | In den Warenkorb legen | |
| Human | HEK293 | Biotinylated Human Prolactin R / PRLR Protein, His,Avitag™ (MALS verified) |  | | | In den Warenkorb legen | |
 Mouse | HEK293 | Mouse Prolactin R / PRLR Protein, His Tag (MALS & SPR verified) |  | |  | In den Warenkorb legen | |
 Cynomolgus | HEK293 | Cynomolgus Prolactin R Protein, His Tag (MALS verified) |  | | | In den Warenkorb legen | |
 Rat | HEK293 | Rat Prolactin R / PRLR Protein, His Tag (MALS & SPR verified) |  | | | In den Warenkorb legen |
Gesamtmenge7
- 1
Prolactin R Molekülhintergrund
The prolactin receptor (PRLR) is a transmembrane protein belonging to the class I cytokine receptor superfamily, widely expressed in mammary gland, reproductive organs, liver, and brain. Signal activation is initiated when a single prolactin (PRL) molecule binds to this pre-dimerized PRLR, inducing a specific conformational change. This triggers the associated JAK2 kinases to phosphorylate each other and the receptor, ultimately leading to the recruitment and activation of downstream STAT5 transcription factors. This precise mechanism governs essential physiological processes, including lactation, reproduction, metabolism, and immune function, and its dysregulation is implicated in diseases such as certain cancers and endometriosis.
Prolactin R Molekülalias
Prolactin R,PRLR,PRL-R
Klinische Arzneimittelinformation
| Englischer Name | Forschungscode | Forschungsphase | Firma | Indikationen | Klinische Studie |
|---|---|---|---|---|---|
| BAY-1158061 | BAY-1158061; HMI-115 | Phase 3 Clinical | Bayer AG | Alopecia; Endometriosis; Pain | Details |
| ABS-201 | ABS-201 | Phase 2 Clinical | Absci Corp | Alopecia; Skin Diseases | Details |
- Molekülinformation
- Produktliste
- Klinische Arzneimittelinformation