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MIF

MIF Overview

English Name	Macrophage migration inhibitory factor	Approved Drugs	1
Drugs in Clinical Trials	3	Target Synonym	EC:5.3.2.1，GIF，EC 5.3.3.12，EC 5.3.2.1，Macrophage Migration-Inhibitory Factors，Epididymis Secretory Sperm Binding Protein，EC:5.3.3.12，Phenylpyruvate Tautomerase，L-Dopachrome Tautomerase，MMIF，Glycosylation-inhibiting factor，L-dopachrome isomerase，MIF，Macrophage Migration Inhibitory Factor，Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor)，GLIF
Highest Development Stage	Approved

English Name	Macrophage migration inhibitory factor
Target Synonym	EC:5.3.2.1，GIF，EC 5.3.3.12，EC 5.3.2.1，Macrophage Migration-Inhibitory Factors，Epididymis Secretory Sperm Binding Protein，EC:5.3.3.12，Phenylpyruvate Tautomerase，L-Dopachrome Tautomerase，MMIF，Glycosylation-inhibiting factor，L-dopachrome isomerase，MIF，Macrophage Migration Inhibitory Factor，Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor)，GLIF
Approved Drugs	1
Drugs in Clinical Trials	3
Highest Development Stage	Approved

MIF Product List

Product Category
Protein (1)
Product Status
Launched (1)
Species
Human (1)
Tag
His Tag & Avi Tag (1)
Conjugate
Biotin-labeled (1)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
MIF-H82E7	Human	HEK293	Biotinylated Human MIF Protein, His,Avitag™

Total: 1

MIF Background

Macrophage migration inhibitory factor(MIF) is also known as Glycosylation-inhibiting factor(GIF), L-dopachrome isomerase, L-dopachrome tautomerase, Phenylpyruvate tautomerase. Interacts with CXCR2 extracellular domain, CD74 extracellular domain, COPS5 and BNIPL. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.

MIF Synonyms

MIF,GLIF,MMIF,GIF

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
IPG-1094	IPG-1094; IPG-001	Phase 2 Clinical	Nanjing Immunophage Biotech Co Ltd	Brain metastases; Brain Neoplasms; Hematologic Neoplasms; Lupus Nephritis; Multiple Myeloma; Multiple Sclerosis; Psoriasis; Solid tumours	Details
TRP2-electroporated autologous dendritic cell therapy (Memorial Sloan-Kettering)		Phase 1 Clinical	Memorial Sloan Kettering Cancer Center	Melanoma	Details
STP-1	STP-1; STP1	Phase 1 Clinical	Stalicla Sa	Autism Spectrum Disorder	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Ibudilast	KC-404; AV-411; MN-166	Approved	Kyorin Pharmaceutical Co Ltd	Ketas, Pinatos, Eyevinal	Japan	Asthma; Multiple Sclerosis; Neuralgia	Kyorin Pharmaceutical Co Ltd		Alcoholism; Amyotrophic Lateral Sclerosis; Asthma; Diabetic Neuropathies; Headache Disorders, Secondary; HIV Infections; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Neuralgia; Opioid-Related Disorders; Pneumonia, Viral; Substance-Related Disorders	Details

Product Reviews

S***n2023-04-28
0People Like
Biotinylated Human MIF Protein, His,Avitag™
This product was used for characterization of a novel therapeutic testing kinetics and affinity on SPR with a Cytiva BiotinCAPture kit. It worked phenomenally with both the novel approach and a positive control. Additionally, it was used with a Streptavidin coated ELISA plate (also from Acro), results were phenomenal with that approach as well. Overall, this product has been well received by our team and we have already ordered more to continue testing.