LTBR

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English

LTBR Molekülinformation

Molecule Name

Tumor necrosis factor receptor superfamily member 3

Molekülalias

LTBR,D12S370,TNFCR,TNFR3,TNFRSF3,TNFRIII

Drug Development Progress

Anzahl der klinischen Arzneimittel1

Anzahl der inverkehr gebrachten Arzneimittel0

Höchste Forschungs- und EntwicklungsphasePhase 1 Clinical

Target-Alias

Lymphotoxin-beta receptor，Tumor necrosis factor receptor type III，LTBR，Tumor necrosis factor receptor superfamily member 3，D12S370，TNFRSF3，TNFCR，TNFR3，TNFR Superfamily， Member 3，Lymphotoxin B Receptor，LT-BETA-R，TNF-R-III，TNFR2-RP，TNF-RIII，TNFR-III，TNFR-RP，Lymphotoxin beta Receptor，Tumor necrosis factor C receptor，Tumor Necrosis Factor Receptor 2-Related Protein，Lymphotoxin Beta Receptor (TNFR Superfamily， Member 3)

Molekülhintergrund

Lymphotoxin-beta receptor (LTBR) is also known as Tumor necrosis factor receptor superfamily member 3 (TNFRSF3), Tumor necrosis factor receptor type III (TNF-RIII), which is a single-pass type I membrane protein containing four TNFR-Cys repeat regions. Except for interacting with HCV core protein, LTBR can not only associate with itself, but also can associate with TRAF3, TRAF4 and TRAF5. As the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT, LTBR promotes apoptosis via TRAF3 and TRAF5. Furthermore, LTBR may play a role in the development of lymphoid organs.