LRP-5

LRP-5 Molekülinformation

Englischer Name	Low-density lipoprotein receptor-related protein 5	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	2	Target-Alias
Höchste Forschungs- und Entwicklungsphase	Phase 3 Clinical

Englischer Name	Low-density lipoprotein receptor-related protein 5
Target-Alias
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	2
Höchste Forschungs- und Entwicklungsphase	Phase 3 Clinical

LRP-5 Produktliste

Attribut
Protein (1)
Produktbibliothek
Online (1)
Spezies
Human (1)
Etikett
His Tag & Avi Tag (1)
Marker
Biotin-labeled (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
LR5-H82E6	Human	HEK293	Biotinylated Human LRP-5 Protein, His,Avitag™ (MALS verified)				In den Warenkorb legen

Gesamtmenge1

Produktanfrage

LRP-5 Molekülhintergrund

Low-density lipoprotein receptor-related protein 5(LRP-5) is also known as BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPTA1, VBCH2, LDL receptor related protein 5 and PCLD4. LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Restoret	EYE103; EYE-103; MK-3000; ANT-39	Phase 3 Clinical	Eyebiotech Ltd	Diabetic macular oedema; Macular Degeneration; Retinal Vein Occlusion	Details
BI-905681	BI-905681	Phase 1 Clinical	Boehringer Ingelheim Ltd	Neoplasms	Details