Klotho beta

Klotho beta Molekülinformation

Englischer Name	Klotho beta	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	3	Target-Alias	Klotho Beta，Klotho Beta-Like Protein，B-Klotho，Klotho Beta Like，Beta-Klotho，EC 3.2.1，BKL，BetaKlotho，KLB
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	Klotho beta
Target-Alias	Klotho Beta，Klotho Beta-Like Protein，B-Klotho，Klotho Beta Like，Beta-Klotho，EC 3.2.1，BKL，BetaKlotho，KLB
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	3
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Klotho beta Produktliste

Attribut
Protein (7)
Produktbibliothek
Online (7)
Spezies
Mouse (2)Cynomolgus / Rhesus macaque (1)Rat (1)Human (2)Rhesus macaque (1)
Etikett
His Tag (7)
Marker
Unconjugated (5)Biotin-labeled (2)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT KLB-H52H4	Human	HEK293	Human Klotho beta / KLB Protein, His Tag	In den Warenkorb legen
HOT KLB-M52H7	Mouse	HEK293	Mouse Klotho beta / KLB Protein, His Tag	In den Warenkorb legen
HOT KLB-R52H8	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque Klotho beta Protein, His Tag (BLI verified)	In den Warenkorb legen
KLB-H82H3	Human	HEK293	Biotinylated Human Klotho beta / KLB Protein, His Tag, ultra sensitivity (primary amine labeling)	In den Warenkorb legen
KLB-M52H3	Mouse	HEK293	Biotinylated Mouse Klotho beta / KLB Protein, His Tag, ultra sensitivity (primary amine labeling) (HPLC verified)	In den Warenkorb legen
KLB-R52H6	Rat	HEK293	Rat Klotho beta / KLB Protein, His Tag	In den Warenkorb legen
KLB-R82H3	Rhesus macaque	HEK293	Biotinylated Rhesus macaque Klotho beta / KLB Protein, His Tag, ultra sensitivity (primary amine labeling)	In den Warenkorb legen

Gesamtmenge7

Klotho beta Molekülhintergrund

KLB (Klotho Beta) is a Protein Coding gene. Among its related pathways are RET signaling and HIV Life Cycle. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and fibroblast growth factor binding. An important paralog of this gene is KL. Klotho Beta is a regulator in multiple metabolic processes, while its role in cancer remains unclear. We found the expression of βKlotho was down-regulated in human hepatocellular carcinoma tissues compared with that in paired adjacent non-tumourous liver tissues. Hepatoma cells also showed decreased expression of βKlotho compared with normal hepatocyte cells. Reintroduction of βKlotho into hepatoma cells inhibited their proliferation.

Klotho beta Molekülalias

betaKlotho,beta-klotho,BKL,KLB,klotho beta like,klotho beta-like protein

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
NGM-313	NGM-313; MK-3655	Phase 2 Clinical	NGM Biopharmaceuticals Inc	Hepatitis; Metabolic Dysfunction-Associated Steatotic Liver Disease; Obesity	Details
JMT-202	JMT202; JMT-202	Phase 2 Clinical	Shanghai Jmt-Bio Inc	Hypertriglyceridemia	Details
DR-10624	DR-10624; DR10624	Phase 2 Clinical	Zhejiang Doer Biologics Corp	Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypertriglyceridemia; Metabolic Dysfunction-Associated Steatotic Liver Disease; Metabolic Syndrome; Obesity; Overweight	Details