IL23A & IL12B

IL23A & IL12B Molekülinformation

Englischer Name	Interleukin-12 subunit beta	Anzahl der inverkehr gebrachten Arzneimittel	8
Anzahl der klinischen Arzneimittel	2	Target-Alias	IL-12B，NK cell stimulatory factor chain 2，IL12B，Interleukin 12B，Interleukin 12B (Natural Killer Cell Stimulatory Factor 2， Cytotoxic Lymphocyte Maturation Factor 2， P40)，Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit，Interleukin-12 Beta Chain，Interleukin 12， P40，IL12， Subunit P40，CLMF P40，NKSF2，Cytotoxic Lymphocyte Maturation Factor 2， P40，Interleukin-12 Subunit Beta，CLMF2，IMD28，IMD29，CLMF，NKSF，Interleukin-12 Subunit p40，Natural Killer Cell Stimulatory Factor， 40 KD Subunit，IL-12 Subunit P40，Natural Killer Cell Stimulatory Factor-2
Höchste Forschungs- und Entwicklungsphase	Approved

Englischer Name	Interleukin-12 subunit beta
Target-Alias	IL-12B，NK cell stimulatory factor chain 2，IL12B，Interleukin 12B，Interleukin 12B (Natural Killer Cell Stimulatory Factor 2， Cytotoxic Lymphocyte Maturation Factor 2， P40)，Cytotoxic Lymphocyte Maturation Factor 40 KDa Subunit，Interleukin-12 Beta Chain，Interleukin 12， P40，IL12， Subunit P40，CLMF P40，NKSF2，Cytotoxic Lymphocyte Maturation Factor 2， P40，Interleukin-12 Subunit Beta，CLMF2，IMD28，IMD29，CLMF，NKSF，Interleukin-12 Subunit p40，Natural Killer Cell Stimulatory Factor， 40 KD Subunit，IL-12 Subunit P40，Natural Killer Cell Stimulatory Factor-2
Anzahl der inverkehr gebrachten Arzneimittel	8
Anzahl der klinischen Arzneimittel	2
Höchste Forschungs- und Entwicklungsphase	Approved

IL23A & IL12B Produktliste

Attribut
Protein (16)
Produktbibliothek
Online (16)
Spezies
Human (3)Human & Mouse (1)Mouse (2)Cynomolgus & Mouse (1)Human & Rat (2)Cynomolgus (2)Rat (1)Rabbit (1)Human | Alpaca (1)Golden Hamster (1)Guinea pig (1)
Etikett
His Tag (12)His Tag & Avi Tag (3)Tag Free (1)
Marker
Unconjugated (13)Biotin-labeled (3)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT ILB-H5219	Human	HEK293	Human IL-23 alpha & IL-12 beta Heterodimer Protein, premium grade	In den Warenkorb legen
HOT ILB-H52W5	Human	HEK293	Human IL-23 alpha&IL-12 beta Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)	In den Warenkorb legen
HOT ILB-H82W6	Human	HEK293	Biotinylated Human IL-23 alpha&IL-12 beta Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)	In den Warenkorb legen
ILB-M52W7	Mouse	HEK293	Mouse IL-23 alpha&IL-12 beta Heterodimer Protein, His Tag&Tag Free (MALS verified)	In den Warenkorb legen
ILB-M82W3	Mouse	HEK293	Biotinylated Mouse IL-23 alpha & IL-12 beta Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)	In den Warenkorb legen
ILB-C52W3	Cynomolgus	HEK293	Cynomolgus IL-23 alpha & IL-12 beta Heterodimer Protein, His Tag&Tag Free (MALS verified)	In den Warenkorb legen
ILB-C82W3	Cynomolgus	HEK293	Biotinylated Cynomolgus IL-23 alpha&IL-12 beta Heterodimer Protein, His,Avitag™&Tag Free (MALS verified)	In den Warenkorb legen
ILB-CM52W8	Cynomolgus & Mouse	HEK293	Cynomolgus IL-23 alpha&Mouse IL-12 beta Heterodimer Protein, His Tag&Tag Free (MALS verified)	In den Warenkorb legen
ILB-G52W3	Guinea pig	HEK293	Guinea pig IL-23 alpha&IL-12 beta Heterodimer Protein, His Tag&Tag Free (MALS verified)	In den Warenkorb legen
ILB-G52W4	Golden Hamster	HEK293	Golden Hamster IL-23 alpha&IL-12 beta Heterodimer Protein, His Tag&Tag Free, low endotoxin (MALS verified)	In den Warenkorb legen

Gesamtmenge16

IL23A & IL12B Molekülhintergrund

Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

IL23A & IL12B Molekülalias

IL-23 alpha & IL-12 beta

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
RO-7837195	RO-7837195; RO7837195	Phase 2 Clinical	Genentech Inc	Colitis, Ulcerative	Details
PF-07261271	RG-6730; PF-07261271	Phase 2 Clinical	Pfizer Inc	Inflammatory Bowel Diseases	Details

Inverkehr gebrachte Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Frühestes Markenname	Frühestes Genehmigungsland	Früheste Indikation	Früheste Genehmigungsgesellschaft	Früheste Genehmigungsdatum	Indikationen	Klinische Studie
Ustekinumab biosimilar (Bio-Thera)	BAT-2206	Approved	Bio-Thera Solutions Ltd	STARJEMZA, Usymro	United States	Plaque psoriasis; Crohn Disease; Colitis, Ulcerative; Arthritis, Psoriatic	Bio-Thera Solutions Ltd	2025-05-22	Arthritis, Psoriatic; Autoimmune Diseases; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	Details
Ustekinumab	C-340; CNTO-1275	Approved	Johnson & Johnson Innovative Medicine	Stelara, 喜达诺	United States	Plaque psoriasis	Janssen Biotech Inc	2009-09-25	Arthritis, Juvenile; Arthritis, Psoriatic; Colitis, Ulcerative; Common Variable Immunodeficiency; Crohn Disease; Dermatitis, Atopic; Dermatomyositis; Diabetes Mellitus, Type 1; Hidradenitis Suppurativa; Ichthyosis; Inflammatory Bowel Diseases; Liver Cirrhosis, Biliary; Lupus Erythematosus, Systemic; Multiple Sclerosis; Palmoplantar pustulosis; Pediatric Crohn's disease; Plaque psoriasis; Polymyositis; Pouchitis; Psoriasis; Sjogren's Syndrome; Spondylitis, Ankylosing; Takayasu Arteritis; Type I Leukocyte Adhesion Defect; Uveitis	Details
Ebdarokimab	AK-101; AK101	Approved		爱达罗	Mainland China	Plaque psoriasis	Zhongshan Akeso Biopharma Co Ltd	2025-04-15	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	Details
Ustekinumab Biosimilar(Celltrion)	CT-P43	Approved	Celltrion Inc	Steqeyma, Steqeyma IV, Qoyvolma	Canada	Arthritis, Psoriatic; Crohn Disease; Plaque psoriasis	Celltrion Inc	2024-08-01	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	Details
Ustekinumab biosimilar (Biocon)	Bmab 1200	Approved	Biocon Biologics Ltd	Yesintek	United States	Colitis, Ulcerative; Crohn Disease; Arthritis, Psoriatic	Biocon Biologics Inc	2024-11-29	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	Details
Ustekinumab biosimilar (Alvotech)	AVT04; AVT-04	Approved	Alvotech hf	Jamteki, Uzpruvo, SELARSDI™, JamtekiTM, Ustekinumab BS (F)	Japan	Arthritis, Psoriatic; Psoriasis	Fuji Pharma Co Ltd	2023-09-25	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	Details
Ustekinumab biosimilar (Samsung Bioepis)	SB-17; SB17	Approved	Samsung Bioepis Co Ltd	Pyzchiva, Eksunbi	EU	Crohn Disease; Colitis, Ulcerative	Samsung Bioepis Nl Bv	2024-04-19	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Gastrointestinal Diseases; Inflammation; Plaque psoriasis; Psoriasis; Rheumatic Diseases; Skin Diseases	Details
Ustekinumab biosimilar (Amgen)	ABP-654; AMG-654	Approved	Amgen Inc	Wezlana, WEZLANA, wezenla, WEZENLA	United States	Crohn Disease; Colitis, Ulcerative; Arthritis, Psoriatic; Plaque psoriasis	Amgen Inc	2023-10-31	Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis; Psoriasis	Details