IL-5

IL-5 Molekülinformation

Englischer Name	Interleukin-5	Anzahl der inverkehr gebrachten Arzneimittel	3
Anzahl der klinischen Arzneimittel	6	Target-Alias	T-cell replacing factor，IL5，Interleukin 5，Eosinophil Differentiation Factor，Colony-Stimulating Factor， Eosinophil，B-Cell Differentiation Factor I，Interleukin-5，IL-5，TRF，Interleukin 5 (Colony-Stimulating Factor， Eosinophil)，B Cell Differentiation Factor I，EDF
Höchste Forschungs- und Entwicklungsphase	Approved

Englischer Name	Interleukin-5
Target-Alias	T-cell replacing factor，IL5，Interleukin 5，Eosinophil Differentiation Factor，Colony-Stimulating Factor， Eosinophil，B-Cell Differentiation Factor I，Interleukin-5，IL-5，TRF，Interleukin 5 (Colony-Stimulating Factor， Eosinophil)，B Cell Differentiation Factor I，EDF
Anzahl der inverkehr gebrachten Arzneimittel	3
Anzahl der klinischen Arzneimittel	6
Höchste Forschungs- und Entwicklungsphase	Approved

IL-5 Produktliste

Attribut
Protein (8)Kits (2)
Produktbibliothek
Online (10)
Spezies
Human (5)Rabbit (1)Mouse (1)Cynomolgus (1)Canine (1)Rat (1)
Etikett
His Tag (6)His Tag & Avi Tag (1)- (2)Tag Free (1)
Marker
Unconjugated (7)Biotin-labeled (1)- (2)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT IL5-H52H3	Human	HEK293	Human IL-5 Protein, His Tag	In den Warenkorb legen
HOT IL5-H82Q5	Human	HEK293	Biotinylated Human IL-5 Protein, His,Avitag™ (MALS verified)	In den Warenkorb legen
HOT IL5-C52H3	Cynomolgus	HEK293	Cynomolgus IL-5 Protein, His Tag, low endotoxin	In den Warenkorb legen
HOT IL5-R52H4	Rabbit	HEK293	Rabbit IL-5 Protein, His Tag	In den Warenkorb legen
CEA-C011	Human	-	Human IL-5 ELISA Kit	In den Warenkorb legen
EP-128	Human	-	IL-5 [Biotinylated] : IL-5Rα Inhibitor Screening ELISA Kit	In den Warenkorb legen
IL5-H5214	Human	HEK293	Human IL-5 Protein, premium grade	In den Warenkorb legen
IL5-M52H3	Mouse	HEK293	Mouse IL-5 Protein, His Tag (MALS verified)	In den Warenkorb legen
IL5-C5243	Canine	HEK293	Canine IL-5 Protein, His Tag (MALS verified)	In den Warenkorb legen
IL5-R5243	Rat	HEK293	Rat IL-5 Protein, His Tag (MALS verified)	In den Warenkorb legen

Gesamtmenge10

IL-5 Molekülhintergrund

Interleukin 5 (IL5) is an interleukin produced by type-2 T helper cells and mast cells. IL-5 is a 115-amino acid (in human, 133 in the mouse) -long TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a homodimer. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, wherein a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed. Given the high concordance of eosinophils and, in particular, allergic asthma pathology, it has been widely speculated that eosinophils have an important role in the pathology of this disease. Drugs that target IL-5 are mepolizumab and reslizumab.

IL-5 Molekülalias

IL-5,TRF,IL5,Interleukin-5

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Recombinant anti-IL-5 humanized monoclonal antibody (Shanghai CP Guojian)	610; SSGJ-610	Phase 3 Clinical	Sunshine GuoJian Pharmaceutical (Shanghai) Co Ltd	Asthma; Autoimmune Diseases	Details
SHR-1703	SHR-1703	Phase 3 Clinical	Jiangsu Hengrui Medicine Co Ltd	Asthma; Eosinophilic Asthma; Eosinophilic Granulomatosis With Polyangiitis	Details
RC-1416	RC14/16; RC-1416	Phase 2 Clinical	Nanjing RegeneCore Biotech Co Ltd	Asthma; Dermatitis, Atopic; Pulmonary Disease, Chronic Obstructive	Details
long-acting anti-IL-5 mAb (GSK)		Phase 1 Clinical	Glaxosmithkline Plc	Asthma	Details
Mepolizumab biosimilar(Bio Thera Solutions)	BAT2606; BAT-2606	Phase 1 Clinical	Bio-Thera Solutions Ltd	Asthma; Autoimmune Diseases; Nasal Polyps; Sinusitis	Details
Mepolizumab biosimilar (CTTQ Pharma)	TQC-3566; TQC3566	Phase 1 Clinical	Nanjing Shunxin Pharmaceuticals Co Ltd Of Chiatai Tianqing Pharmaceutical Group	Asthma; Eosinophilic Granuloma; Eosinophilic Granulomatosis With Polyangiitis; Granulomatosis with Polyangiitis; Hypereosinophilic Syndrome; Lymphohistiocytosis, Hemophagocytic; Nasal Polyps; Sinusitis; Vasculitis	Details

Inverkehr gebrachte Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Frühestes Markenname	Frühestes Genehmigungsland	Früheste Indikation	Früheste Genehmigungsgesellschaft	Früheste Genehmigungsdatum	Indikationen	Klinische Studie
Reslizumab	CEP-38072; SCH-5570; TRFK-5; SCH-55700; CDP-835; CTx-55700	Approved	Teva Pharmaceutical Industries Ltd	Cinquil, Cinqair, Cinqaero	United States	Asthma	Teva Respiratory Llc	2016-03-23	Asthma; Bronchitis; Eosinophilic Esophagitis; Hypereosinophilic Syndrome; Loiasis; Pulmonary Eosinophilia	Details
Depemokimab	GSK-3511294; AQ82742999; GSK3511294; GSK-294; GSK294	Approved	Glaxosmithkline Plc	易适来, Exdensur	United Kingdom	Asthma; Sinusitis; Nasal Polyps	Glaxosmithkline Plc	2025-12-15	Asthma; Chronic rhinosinusitis with nasal polyps (CRSwNP); Eosinophilic Asthma; Eosinophilic Granuloma; Eosinophilic Granulomatosis With Polyangiitis; Hypereosinophilic Syndrome; Nasal Polyps; Pulmonary Disease, Chronic Obstructive; Sinusitis; Vasculitis	Details
Mepolizumab	SB-240563; 240563	Approved	Glaxosmithkline Plc	Bosatria, Nucala, 美泊利珠单抗, 新可来	United States	Asthma	Glaxosmithkline Llc	2015-11-04	Angioedema; Asthma; Bronchitis; Chronic rhinosinusitis with nasal polyps (CRSwNP); Chronic Urticaria; Dermatitis, Atopic; Eosinophilia; Eosinophilic Esophagitis; Eosinophilic Granulomatosis With Polyangiitis; Fasciitis; Granulomatosis with Polyangiitis; Hypereosinophilic Syndrome; Nasal Polyps; Pulmonary Disease, Chronic Obstructive; Sinusitis; Virus Diseases	Details