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Canine IL-5 Protein, His Tag (MALS verified)

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Product Number/Spec
Price
Menge
IL5-C5243-50ug
$360.00
IL5-C5243-1mg
$2720.00
ETA of in-stock products:2 business days
Gesamtanzahl Product Amount$ 0

Product Details

  • Synonyms

    IL-5, TRF, IL5, Interleukin-5

  • Source

    Canine IL-5 Protein, His Tag (IL5-C5243) is expressed from human 293 cells (HEK293). It contains AA Val 22 - Ser 134 (Accession # Q95J76).

    Predicted N-terminus: His

    Request for sequence
  • Molecular Characterization

    IL-5 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 15.0 kDa. The protein migrates as 14 kDa and 17-20 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

    The protein is designed as a dimer.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Data Display

  • SDS-PAGE

    IL-5 SDS-PAGE

    Canine IL-5 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    IL-5 SEC-MALS

    The purity of Canine IL-5 Protein, His Tag (Cat. No. IL5-C5243) is more than 90% and the molecular weight of this protein is around 28-38 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     IL-5 ELISA

    Immobilized Human IL-5 R alpha, Fc Tag (Cat. No. ILA-H5269) at 5 μg/mL (100 μL/well) can bind Canine IL-5 Protein, His Tag (Cat. No. IL5-C5243) with a linear range of 0.02-1.25 μg/mL (QC tested).

    Protocol

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Publish Comment

Background Introduction

Interleukin 5 (IL5) is an interleukin produced by type-2 T helper cells and mast cells. IL-5 is a 115-amino acid (in human, 133 in the mouse) -long TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a homodimer. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, wherein a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed. Given the high concordance of eosinophils and, in particular, allergic asthma pathology, it has been widely speculated that eosinophils have an important role in the pathology of this disease. Drugs that target IL-5 are mepolizumab and reslizumab.

Frontier Progress

 
Drug Development Progress
  • English Name:

    Interleukin-5

  • Category:

  • Listed Drugs Count:

    3 Details

  • Clinical Drugs Count:

    6 Details

  • Highest R&D Stage:

    Approved

Drug Candidate Licensing
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