DR3

DR3 Produktliste

Attribut
Protein (7)Cell (1)
Produktbibliothek
Online (8)
Spezies
Cynomolgus (2)Human (5)Mouse (1)
Etikett
Fc Tag (2)His Tag (3)- (1)Fc Tag & Avi Tag (1)His Tag & Avi Tag (1)
Marker
Unconjugated (5)- (1)Biotin-labeled (2)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT AIDD‑Ready DR3-H5253	Human	HEK293	Human DR3 Protein, Fc Tag, low endotoxin (MALS verified)	In den Warenkorb legen
HOT AIDD‑Ready DR3-H82E3	Human	HEK293	Biotinylated Human DR3 / TNFRSF25 Protein, His,Avitag™ (MALS verified)	In den Warenkorb legen
HOT AIDD‑Ready TN5-H52H3	Human	HEK293	Human DR3 / TNFRSF25 Protein, His Tag, low endotoxin (Mass Spec & MALS verified)	In den Warenkorb legen
AIDD‑Ready DR3-H82F3	Human	HEK293	Biotinylated Human DR3 / TNFRSF25 Protein, Fc,Avitag™ (MALS verified)	In den Warenkorb legen
SCJUR-STF178	Human	Jurkat	Human DR3 (TL1A receptor) (Luc) Jurkat Reporter Cell	In den Warenkorb legen
AIDD‑Ready DR3-M52H3	Mouse	HEK293	Mouse DR3 / TNFRSF25 Protein, His Tag, low endotoxin (HPLC & SPR verified)	In den Warenkorb legen
AIDD‑Ready DR3-C52H3	Cynomolgus	HEK293	Cynomolgus DR3 / TNFRSF25 Protein, His Tag, low endotoxin (SPR verified)	In den Warenkorb legen
TN5-C5257	Cynomolgus	HEK293	Cynomolgus DR3 / TNFRSF25 Protein, Fc Tag, low endotoxin	In den Warenkorb legen

Gesamtmenge8

Produktanfrage

DR3 Molekülhintergrund

Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) is also known as Apo-3, Death receptor 3 (DDR3 or DR3), Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor TRAMP, Lymphocyte-associated receptor of death, Apo-3, which is a member of the TNF-receptor superfamily. TNFRSF25 is a homodimer protein, which can Interact strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. TNFRSF25 is receptor for TNFSF12 / APO3L / TWEAK.

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Ontamalimab	SHP-647; PF-00547659; PF-547659	Phase 3 Clinical	Pfizer Inc	Ileitis; Colitis, Ulcerative; Crohn Disease	Details
Vedolizumab biosimilar (Polpharma Biologics)	PB-016	Phase 3 Clinical	Polpharma Biologics Sa	Pouchitis; Colitis, Ulcerative; Crohn Disease	Details

Inverkehr gebrachte Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Frühestes Markenname	Frühestes Genehmigungsland	Früheste Indikation	Früheste Genehmigungsgesellschaft	Früheste Genehmigungsdatum	Indikationen	Klinische Studie
Vedolizumab	MLN-0002; LPD-02; MLN-002; MLN-02; LDP-02	Approved	Millennium Pharmaceuticals Inc	安吉优, Entyvio	United States	Colitis, Ulcerative; Crohn Disease	Takeda Pharmaceuticals USA Inc	2014-05-20	Celiac Disease; Carcinoma, Non-Small-Cell Lung; Melanoma; Crohn Disease; Gastritis; Urogenital Neoplasms; Colitis, Ulcerative; Cholangitis, Sclerosing; Pediatric ulcerative colitis; Solid tumours; Colitis; Pouchitis; Neoplasms; Pediatric Crohn's disease; Inflammatory Bowel Diseases; HIV Infections; Hematopoietic stem cell transplantation (HSCT)	Details