Claudin-6

Claudin-6 Molekülinformation

Englischer Name	Claudin 6	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	13	Target-Alias	UNQ757/PRO1488，Claudin-6，CLDN6，Claudin 6，Skullin
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	Claudin 6
Target-Alias	UNQ757/PRO1488，Claudin-6，CLDN6，Claudin 6，Skullin
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	13
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Claudin-6 Produktliste

Attribut
Protein (10)Cell (1)
Produktbibliothek
Online (11)
Spezies
Human (11)
Etikett
His Tag & Strep Tag (2)His Tag & Flag Tag & GFP Tag (2)GFP Tag (1)- (5)Flag Tag & His Tag & Strep Tag (1)
Marker
Unconjugated (5)GFP Fusion (2)- (1)Biotin-labeled (3)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT CHEK-ATP138	Human	HEK293	HEK293/Human Claudin-6 Stable Cell Line	In den Warenkorb legen
HOT CL6-H5289	Human	InsectCells	Human Claudin-6 / CLDN6 Full Length Protein, His,Twin-Strep Tag (Detergent)	In den Warenkorb legen
HOT CL6-H52P7	Human	HEK293	Human Claudin-6 / CLDN6 Full Length Protein (VLP)	In den Warenkorb legen
CL6-H5286	Human	InsectCells	Human Claudin-6 / CLDN6 Full Length Protein, His,Twin-Strep Tag (Nanodisc)	In den Warenkorb legen
CL6-H52D3	Human	HEK293	Human Claudin-6 Full Length Protein, Flag,His Tag&Twin-Strep Tag (Nanodisc-pro)	In den Warenkorb legen
CL6-H52M3	Human	HEK293	Fluorescent Human Claudin-6 Full Length Protein, Flag,His Tag,GFP Tag (Nanodisc-pro)	In den Warenkorb legen
CL6-H82P3	Human	HEK293	Biotinylated Human Claudin-6 / CLDN6 Full Length Protein (VLP)	In den Warenkorb legen
CL6-H85D3	Human	InsectCells	Biotinylated Human Claudin-6 Full Length Protein, His,Avitag™&Flag Tag (Detergent)	In den Warenkorb legen
CL6-H85D4	Human	InsectCells	Biotinylated Human Claudin-6 Full Length Protein, His,Avitag™&Flag Tag (Nanodisc)	In den Warenkorb legen
CL6-HF2G8	Human	HEK293	Fluorescent Human Claudin-6 / CLDN6 Full Length Protein (VLP)	In den Warenkorb legen

Gesamtmenge11

Claudin-6 Molekülhintergrund

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Claudin-6, also knows as CLDN6, is a multipass transmembrane protein in the Claudin family. Claudin-6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. And it is one of the entry cofactors for hepatitis C virus. The methylation of CLDN6 may be involved in esophageal tumorigenesis. The gene of CLDN6 is adjacent to another family member CLDN9 on chromosome 16.

Claudin-6 Molekülalias

Claudin-6,CLDN6

Antikörperprojekt-Handelsplattform

Projektname	Projektphase	Molekültyp	Molekülquelle	Krankheitsgebiet	Indikationen
CLDN6 mAb - 01	PCC	Monoclonal	Humanized Mouse	Solid Tumor	Ovarian cancer,Lung adenocarcinoma

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
QLS-5132	QLS5132; QLS-5132	Phase 2 Clinical	Qilu Pharmaceutical Co Ltd	Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Ovarian Neoplasms; Solid tumours; Stomach Neoplasms	Details
TORL-1-23	TORL-1-23	Phase 2 Clinical	Torl Biotherapeutics LLC	Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Endometrial Neoplasms; Fallopian Tube Diseases; Fallopian Tube Neoplasms; Ovarian Neoplasms; Peritoneal Diseases; Peritoneal Neoplasms; Solid tumours	Details
PLB-002	PLB-002; PLB002	Phase 1 Clinical	PrimeLink BioTherapeutics	Endometrial Neoplasms; Ovarian Neoplasms; Solid tumours; Testicular Neoplasms	Details
BGB-B455	BGB-B455	Phase 1 Clinical	BeOne Medicines Ltd	Solid tumours	Details
AT03-65	AT-03-65; AT03-65	Phase 1 Clinical	Axcynsis Therapeutics Pte Ltd	Solid tumours	Details
ARC-101	ARC101; ARC-101	Phase 1 Clinical	Third Arc Bio Inc	Endometrial Neoplasms; Lung Neoplasms; Ovarian Neoplasms; Solid tumours	Details
CTIM-76	CTIM-76	Phase 1 Clinical	Integral Molecular Inc	Endometrial Neoplasms; Neoplasms; Ovarian Neoplasms; Solid tumours; Testicular Neoplasms	Details
NBL-028	NBL028; NBL-028	Phase 1 Clinical	Novarock Biotherapeutics Ltd, Shanghai Xinshi Biological Medicine Co Ltd	Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Neoplasms; Ovarian Neoplasms; Solid tumours; Stomach Neoplasms; Testicular Neoplasms	Details
XmAb-541	XmAb541; XmAb-541	Phase 1 Clinical	Xencor Inc	Endometrial Neoplasms; Germinoma; Neoplasms, Germ Cell and Embryonal; Ovarian germ cell tumor; Ovarian Neoplasms	Details
SAIL-66	SAIL66; SAIL-66	Phase 1 Clinical	Chugai Pharmaceutical Co Ltd	Solid tumours	Details
CLDN6-CAR-NK Cell Therapy		Phase 1 Clinical	Second Affiliated Hospital Of Guangzhou Medical University	Endometrial Neoplasms; Ovarian Neoplasms	Details
TJ-C64B	TJ-C64B	Phase 1 Clinical	I-Mab Biopharma Co Ltd	Ovarian Neoplasms; Stomach Neoplasms	Details
CLDN6 CAR-T cell therapy (BioNTech)	BNT-211	Phase 1 Clinical	Biontech Se	Germinoma; Neoplasms, Gonadal Tissue; Solid tumours; Testicular Neoplasms	Details