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CD45

CD45

CD45 Overview

Molecule Name
Leukocyte common antigen
Synonyms
CD45,PTPRC,L-CA,T200
Drug Development Progress
Drugs in Clinical Trials7
Approved Drugs0
Highest Development StagePhase 3 Clinical
Target Synonym
PTPRC，T200，CD45，Protein Tyrosine Phosphatase， Receptor Type C，CD45 Antigen，L-CA，Protein Tyrosine Phosphatase， Receptor Type， C Polypeptide，Receptor-Type Tyrosine-Protein Phosphatase C，T200 Leukocyte Common Antigen，Leukocyte Common Antigen，T200 Glycoprotein，EC 3.1.3.48，CD45R，GP180，B220，LCA，LY5，Leukocyte Common Antigens，Protein Tyrosine Phosphatase Receptor Type C，EC:3.1.3.48
Background
CD45 is a receptor protein tyrosine phosphatase, also known as Ly-5 or leukocyte common antigen. CD45 mainly involves in the initiation of T cell receptor signaling by controlling the activation of the Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency causes in T- and B-lymphocyte dysfunction in the form of severe combined immune deficiency. It also takes a significant role in autoimmune diseases and cancer as well as in infectious diseases including fungal infections.

CD45 Product List

Species
  • Human（4）
  • Mouse（1）
Tag
  • His Tag（2）
  • His Tag & Avi Tag（2）
  • Llama IgG Fc Tag（1）
Host
  • HEK293（5）
Conjugate
  • Unconjugated（3）
  • Biotin-labeled（2）
Grade
  • RUO（5）
Low Endotoxin
  • Yes（1）
  • No（4）
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&Price
CD45
HOT
CD5-H5259
Human CD45 / PTPRC Protein, Llama IgG2b Fc Tag
Human
HEK293
SDS-PAGE

$410.00

100ug
CD45
HOTAIDD‑Ready
CD5-H52H8
Human CD45 / PTPRC protein, His Tag, low endotoxin (MALS & BLI verified)
Human
HEK293
MALSSDS-PAGE
BLI

$395.00

100ug
CD45
HOTAvitagAIDD‑Ready
CD5-H82E7
Biotinylated Human CD45 / PTPRC protein, His,Avitag™ (MALS verified)
Human
HEK293
MALSSDS-PAGE
BLI

$415.00

25ug
CD45
Avitag
CD5-H82E8
Biotinylated Human CD45 / PTPRC Protein, His,Avitag™
Human
HEK293
SDS-PAGE

$360.00

25ug
CD45
AIDD‑Ready
CD5-M52H3
Mouse CD45 / PTPRC protein, His Tag (MALS & SPR verified)
Mouse
HEK293
MALSSDS-PAGE
SPR

$385.00

100ug
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Resources

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
Immunomodulatory progenitor cell therapy (Celixir)Phase 3 ClinicalCelixir
Cardiomyopathies; Endomyocardial Fibrosis
Details
I-131-ApamistamabBC8-I-131; BC-8; 131IBC8; I-131 BC-8Phase 3 ClinicalFred Hutchinson Cancer Research Center
Anemia, Refractory, with Excess of Blasts; Anemia, Sickle Cell; Anemia, Sideroblastic; Angioimmunoblastic T-cell Lymphoma; Burkitt Lymphoma; Graft vs Host Disease; Hematopoietic stem cell transplantation (HSCT); Hodgkin Disease; Intraocular Lymphoma; Leukemia; Leukemia, Hairy Cell; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia-Lymphoma, Adult T-Cell; Lymphoma; Lymphoma, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Extranodal NK-T-Cell; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Large-Cell, Immunoblastic; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Lymphomatoid Granulomatosis; Mycosis Fungoides; Myelodysplastic Syndromes; Neoplasms, Gonadal Tissue; Neoplastic Cells, Circulating; Pancytopenia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sezary Syndro
Details
At 211 MAb BC8-B10Phase 2 ClinicalFred Hutchinson Cancer Research Center
Neoplasms
Details
211At-BC8-B10211At-BC8-B10Phase 2 ClinicalFred Hutchinson Cancer Research Center, National Cancer Institute
Hematologic Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Details
CD45BE-HSPC cells therapy (Kite Pharma)Phase 1 ClinicalKite Pharma
Hodgkin Disease; Lymphoma, B-Cell; Lymphoma, T-Cell; Richter's Syndrome
Details
CART-45 cells therapy (Kite Pharma)Phase 1 ClinicalKite Pharma
Hodgkin Disease; Lymphoma, B-Cell; Lymphoma, T-Cell; Richter's Syndrome
Details
TSC-102TSC-102-A03; TSC-102-A0301; TSC-102; TSC-102-A01Phase 1 ClinicalTScan Therapeutics Inc
Hematologic Neoplasms; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma
Details
Customer Reviews
  • n***l2025-10-31
    Biotinylated Human CD45 / PTPRC protein, His,Avitag™ (MALS verified)
    The technical team was quick to respond to my question regarding my experimental plan to use the biotinylated CD45 PTPRC protein. The biotinylated protein was immobilized on the SA biosensor of Octet BLI R8 to measure the binding affinity of anti-human CD45RA antibody. The assay worked on the first try!
  • N***o2023-05-13
    Human CD45 / PTPRC protein, His Tag, low endotoxin (MALS & BLI verified)
    We were very satisfied with the whole process of purchasing and utilizing the product as we had no issues with shipping time or product packaging. We used the protein to assist in the development of LFAs detecting for CD45 on cells. Pairs of anti-CD45 antibodies were first tested using the protein to help us determine which pair of antibodies produced the best results. These tests allowed us to move forward with designing full LFAs.
  • L***h2021-12-13
    Biotinylated Human CD45 / PTPRC protein, His,Avitag™ (MALS verified)
    Dear Sir or Madam, I had an overall good service from Acro Biosystems. Shipment was fast and product quality was good. Got the protocol for QC after asking the customer service. Protocol for QC was easy to understand and repeat. Easy way to download the Certificate of Analysis via the printed QR code on product vials. Customer service answered very fast and was very friendly. QC of biotinylated human CD45 protein vs. Human Galectin-1 protein (GA1-H4113) was fine. Biotinylated human CD45 protein worked fine and could be loaded on Streptavidin biosensors (Octet system).