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B7-H5

B7-H5 Overview

English Name	V-domain Ig suppressor of T-cell activation	Approved Drugs	0
Drugs in Clinical Trials	8	Target Synonym	Dies1，VSIR，V-Set Domain-Containing Immunoregulatory Receptor，DD1alpha，B7-H5，PD-1H，B7H5，GI24，Stress-induced secreted protein-1，PP2135，SISP1，UNQ730/PRO1412，V-type immunoglobulin domain-containing suppressor of T-cell activation，V-Set Immunoregulatory Receptor，V-Domain Ig Suppressor Of T Cell Activation，PDCD1 Homolog，C10orf54，Sisp-1，VISTA，Chromosome 10 Open Reading Frame 54，Stress Induced Secreted Protein 1，Platelet Receptor Gi24，Death Domain1alpha
Highest Development Stage	Phase 3 Clinical

English Name	V-domain Ig suppressor of T-cell activation
Target Synonym	Dies1，VSIR，V-Set Domain-Containing Immunoregulatory Receptor，DD1alpha，B7-H5，PD-1H，B7H5，GI24，Stress-induced secreted protein-1，PP2135，SISP1，UNQ730/PRO1412，V-type immunoglobulin domain-containing suppressor of T-cell activation，V-Set Immunoregulatory Receptor，V-Domain Ig Suppressor Of T Cell Activation，PDCD1 Homolog，C10orf54，Sisp-1，VISTA，Chromosome 10 Open Reading Frame 54，Stress Induced Secreted Protein 1，Platelet Receptor Gi24，Death Domain1alpha
Approved Drugs	0
Drugs in Clinical Trials	8
Highest Development Stage	Phase 3 Clinical

B7-H5 Product List

Product Category
Protein (7)
Product Status
Launched (7)
Species
Human (5)Rhesus macaque (1)Mouse (1)
Tag
His Tag (3)Fc Tag (1)His Tag & Avi Tag (1)Fc Tag & Avi Tag (1)Mouse IgG Fc Tag (1)
Conjugate
Unconjugated (5)Biotin-labeled (2)

Cat. No.	Species	Host	Product Description
HOT B75-H5258	Human	HEK293	Human B7-H5 / Gi24 / VISTA Protein, Mouse IgG2a Fc Tag, low endotoxin
HOT B75-H5259	Human	HEK293	Human B7-H5 / Gi24 / VISTA Protein, Fc Tag
HOT B75-H52H0	Human	HEK293	Human B7-H5 / Gi24 / VISTA Protein, His Tag (MALS verified)
HOT B75-H82E1	Human	HEK293	Biotinylated Human B7-H5 / Gi24 / VISTA Protein, Avitag™,His Tag
HOT B75-H82F3	Human	HEK293	Biotinylated Human B7-H5 / Gi24 / VISTA Protein, Fc,Avitag™
B75-M52H7	Mouse	HEK293	Mouse B7-H5 / Gi24 / VISTA Protein, His Tag
B75-C5220	Rhesus macaque	HEK293	Rhesus macaque B7-H5 / Gi24 / VISTA Protein, His Tag

Total: 7

B7-H5 Background

Platelet receptor Gi24, also known as B7-H5 and stress-induced secreted protein-1 (Sisp-1), is a protein that in humans is encoded by the C10orf54 gene, which contains 1 Ig-like (immunoglobulin-like) domain. As for C10orf54 gene, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state on ESCs. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.

B7-H5 Synonyms

B7-H5,SISP1,Gi24,VISTA

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
CA-170	CA-170; AUPM-170	Phase 3 Clinical	Aurigene	Carcinoma, Non-Small-Cell Lung; Neoplasms; Solid tumours	Details
Solnerstotug	SNS-101; SNS-VISTA	Phase 2 Clinical	Sensei Biotherapeutics Inc	Breast Neoplasms; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Esophageal Neoplasms; Head and Neck Neoplasms; Kidney Neoplasms; Melanoma; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Sarcoma; Solid tumours; Stomach Neoplasms; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms	Details
Trovostobart	KVA-12123; KVA-12.1	Phase 2 Clinical	GigaGen Inc	Breast Neoplasms; Carcinoma; Colorectal Neoplasms; Esophageal Neoplasms; Head and Neck Neoplasms; Kidney Neoplasms; Lung Neoplasms; Melanoma; Neoplasms; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Sarcoma; Solid tumours; Stomach Neoplasms; Thyroid Neoplasms; Uterine Neoplasms	Details
Onvatilimab	CI-8993; JNJ-61610588	Phase 1 Clinical	Immunext Inc, Johnson & Johnson Innovative Medicine	Neoplasms; Solid tumours	Details
HMBD-002	HMBD-002	Phase 1 Clinical	Hummingbird Bioscience	Carcinoma, Non-Small-Cell Lung; Neoplasm Metastasis; Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	Details
PMC-309	PMC-309	Phase 1 Clinical	Pharmabcine	Neoplasms; Solid tumours	Details
TBS-2025	TBS-2025	Phase 1 Clinical	Kintara Therapeutics Inc	Leukemia, Myeloid, Acute	Details
LFD-200	LFD-200	Phase 1 Clinical	Lifordi Immunotherapeutics Inc	Arthritis, Rheumatoid	Details