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B7-H4

B7-H4 Overview

English Name	V-set domain-containing T-cell activation inhibitor 1	Approved Drugs	0
Drugs in Clinical Trials	11	Target Synonym	V-Set Domain-Containing T-Cell Activation Inhibitor 1，Immune costimulatory protein B7-H4，B7h.5，B7 homolog 4，T-cell costimulatory molecule B7x，V-Set Domain Containing T Cell Activation Inhibitor 1，B7X，B7 Family Member， H4，T Cell Costimulatory Molecule B7x，B7S1，B7 Superfamily Member 1，VCTN1，PRO1291，FLJ22418，B7H4，B7-H4，Protein B7S1
Highest Development Stage	Phase 3 Clinical

English Name	V-set domain-containing T-cell activation inhibitor 1
Target Synonym	V-Set Domain-Containing T-Cell Activation Inhibitor 1，Immune costimulatory protein B7-H4，B7h.5，B7 homolog 4，T-cell costimulatory molecule B7x，V-Set Domain Containing T Cell Activation Inhibitor 1，B7X，B7 Family Member， H4，T Cell Costimulatory Molecule B7x，B7S1，B7 Superfamily Member 1，VCTN1，PRO1291，FLJ22418，B7H4，B7-H4，Protein B7S1
Approved Drugs	0
Drugs in Clinical Trials	11
Highest Development Stage	Phase 3 Clinical

B7-H4 Product List

Product Category
Protein (11)Cell (1)
Product Status
Launched (12)
Species
Human (5)Mouse (3)Cynomolgus / Rhesus macaque (2)Rat (1)Canine (1)
Tag
His Tag (7)His Tag & Avi Tag (3)Fc Tag (1)- (1)
Conjugate
Unconjugated (6)Biotin-labeled (4)Azide Labeled (1)- (1)

Cat. No.	Species	Host	Product Description
HOT B74-H5222	Human	HEK293	Human B7-H4 Protein, His Tag, low Endotoxin (MALS verified)
HOT B74-H5256	Human	HEK293	Human B7-H4 Protein, Fc Tag, low endotoxin
HOT B74-H82E2	Human	HEK293	Biotinylated Human B7-H4 Protein, Avitag™,His Tag (recommended for biopanning) (MALS verified)
HOT B74-M52H9	Mouse	HEK293	Mouse B7-H4 Protein, His Tag
HOT B74-C52H9	Cynomolgus / Rhesus macaque	HEK293	Cynomolgus / Rhesus macaque B7-H4 Protein, His Tag, low endotoxin (MALS verified)
B74-H8222	Human	HEK293	Biotinylated Human B7-H4 Protein, His Tag, ultra sensitivity (primary amine labeling) (MALS verified)
CHEK-ATP126	Human	HEK293	HEK293/Human B7-H4 Stable Cell Line
B74-M52H7	Mouse	HEK293	Azide-labeled Mouse B7-H4 Protein, His TagStar Staining (MALS verified)
B74-M82E3	Mouse	HEK293	Biotinylated Mouse B7-H4 Protein, His,Avitag™
B74-C52H8	Canine	HEK293	Canine B7-H4 Protein, His Tag (MALS verified)

Total: 12

B7-H4 Background

V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

B7-H4 Synonyms

B7-H4,VTCN1,B7S1,B7h.5

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Puxitatug Samrotecan	AZD8205; AZD-8205	Phase 3 Clinical	Astrazeneca Plc	Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Neoplasm Metastasis; Ovarian Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	Details
Mocertatug Rezetecan	HS-20089; GSK-5733584; GSK5733584	Phase 3 Clinical	Shanghai Hansoh Biomedical Co Ltd	Breast Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Genital Neoplasms, Female; Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms	Details
ABL-103	ABL-103	Phase 2 Clinical	Abl Bio Inc, Handok Inc	Solid tumours	Details
MHB-009C	MHB-009C; MHB009C	Phase 2 Clinical	Minghui Pharmaceutical (Hangzhou) Co Ltd	Solid tumours	Details
GEN-1047	GEN-1047	Phase 2 Clinical	Genmab A/S	Endometrial Neoplasms	Details
DB-1312	BG-C9074; DB-1312	Phase 1 Clinical	Duality Biologics (Suzhou) Co Ltd	Solid tumours	Details
LNCB-74	LNCB-74; LNCB74; LCB41A	Phase 1 Clinical	LigaChem Biosciences Inc, Nextcure Inc	Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Neoplasms; Ovarian Neoplasms; Solid tumours	Details
XKH-002	XKH-002; XKH002	Phase 1 Clinical	Beijing Kanova Biomedical Technology Co Ltd, Zhejiang Kanova Biopharmaceutical Co Ltd	Neoplasms; Solid tumours	Details
Felmetatug vedotin	SGN-B7H4V; PF-08046048; SGN-B-7H-4V; SGNB-7H4V; SGNB-7H-4V	Phase 1 Clinical	Seagen Inc	Breast Neoplasms; Carcinoma, Adenoid Cystic; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	Details
Emiltatug Ledadotin	XMT-1660	Phase 1 Clinical	Mersana Therapeutics Inc	Abdominal Neoplasms; Breast Neoplasms; Carcinoma, Adenoid Cystic; Endometrial Neoplasms; Fallopian Tube Neoplasms; Neoplasms; Ovarian Neoplasms; Triple Negative Breast Neoplasms	Details
HBM-7008	HBM7008; HBM-7008; R-7008; CLN-418	Phase 1 Clinical	Harbour Biomed	Solid tumours	Details

Product Reviews

1***12019-11-16
5People Like
Biotinylated Human B7-H4 Protein, Avitag™,His Tag (recommended for biopanning) (MALS verified)
We purchased total of 600ug of this biotin-labeled antigen for liquid phase panning and antibody screening of affinity maturation. This antigen has good stability, high quality, and high repeatability for each experiment. Using this antigen, we screened high-affinity antibodies against this target. And using this antigen for screening of affinity maturation, we obtained antibodies with 10-times increased affinity. I highly recommended this product.