Azide-labeled Mouse B7-H4 Protein, His TagStar Staining (MALS verified)

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Cat. No. / Size
Price
Qty
B74-M52H7-100ug
$645.00
B74-M52H7-500ug (250ug X 2)
$2575.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    B7-H4, VTCN1, B7S1, B7h.5

  • Source

    Azide-labeled Mouse B7-H4 Protein, His Tag (B74-M52H7) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Gly 257 (Accession # Q7TSP5-1).

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  • Molecular Characterization

    B7-H4 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    B7-H4 SDS-PAGE

    Azide-labeled Mouse B7-H4 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    B7-H4 SEC-MALS

    The purity of Azide-labeled Mouse B7-H4 Protein, His Tag (Cat. No. B74-M52H7) is more than 85% and the molecular weight of this protein is around 58-70 kDa verified by SEC-MALS.

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Background

V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.

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Drug Development Progress
  • English Name:

    V-set domain-containing T-cell activation inhibitor 1

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    11 Details

  • Highest Development Stage:

    Phase 3 Clinical

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