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Human Transferrin R2 alpha protein, His Tag

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Menge
TRA-H5243-100ug
$360.00
In Stock - Delivery in 1-2 business days
TRA-H5243-1mg (500ug X 2)
$2,380.00
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TRA-H5243
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Synonyms

TfR2

Source

Human Transferrin R2 alpha protein, His Tag (TRA-H5243) is expressed from human 293 cells (HEK293). It contains AA Gly 112 - Phe 801 (Accession # Q9UP52-1).

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 78.4 kDa. The protein migrates as 80-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>90% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, 0.2 M Arginine, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background Introduction

Transferrin R2 alpha, also known as TfR2α, is a type II transmembrane protein localized to the cell membrane and is primarily expressed in hepatocytes and erythroid precursors. Its functions include the uptake of iron-bound transferrin, acting as an iron-level sensor to regulate hepcidin for maintaining systemic iron homeostasis, and negatively regulating erythropoiesis. This protein is closely associated with diseases such as type 3 hereditary hemochromatosis, anemia, and β-thalassemia.