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HCoV-OC43 Spike protein, His Tag

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Product Number/Spec
Price
Menge
SPN-H52Hz-50ug
$465.00
SPN-H52Hz-500ug
$3170.00
ETA of in-stock products:2 business days
Gesamtanzahl Product Amount$ 0

Product Details

  • Synonyms

    Spike, S protein, Spike glycoprotein, S glycoprotein

  • Source

    HCoV-OC43 Spike protein, His Tag (SPN-H52Hz) is expressed from Baculovirus-Insect cells. It contains AA Ala 14 - Pro 1297 (RRSRG 754-758 GGSGG) (Accession # P36334-1).

    Predicted N-terminus: Ala 14

    Request for sequence
  • Molecular Characterization

    Spike protein Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 148.3 kDa. The protein migrates as 170 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 0.1 M Sodium citrate, pH5.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Data Display

  • SDS-PAGE

    Spike protein SDS-PAGE

    HCoV-OC43 Spike protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

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Publish Comment

Background Introduction

Human coronavirus OC43 (HCoV-OC43) is one of seven known coronaviruses to infect humans, which is responsible for the common cold and may have been responsible for the 1889–1890 pandemic. The infecting coronavirus is an enveloped, positive-sense, single-stranded RNA virus that enters its host cell by binding to the N-acetyl-9-O-acetylneuraminic acid receptor. The spike protein of HCoV-OC43 is a trimer protruding from the viral membrane to engage cellular receptors and mediate viral fusion with host membranes. Each spike trimer contains two large regions: N-terminal S1 responsible for receptor binding and C-terminal S2 responsible for fusion.

Frontier Progress

 
Drug Development Progress
  • English Name:

    Coronavirus spike glycoprotein

  • Category:

  • Listed Drugs Count:

    15 Details

  • Clinical Drugs Count:

    88 Details

  • Highest R&D Stage:

    Approved

Drug Candidate Licensing
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