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Human Parkin Protein, His Tag

Cat. No. / Size
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PAN-H5543-100ug
$340.00
In Stock - Delivery in 1-2 business days
PAN-H5543-500ug
$1,280.00
In Stock - Delivery in 2-3 weeks
PAN-H5543
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

AR-JP, LPRS2, PARK2, PDJ

Source

Human Parkin Protein, His Tag (PAN-H5543) is expressed from Baculovirus-Insect cells. It contains AA Ile 2 - Val 465 (Accession # O60260-1).

Predicted N-terminus: Met

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the N-terminus.

The protein has a calculated MW of 53.5 kDa. The protein migrates as 55-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity

>85% as determined by SDS-PAGE.

Formulation

Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with glycerol as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 3 months under sterile conditions.
ACRO Quality Management System

Background

Parkin is an E3 ubiquitin ligase encoded by the PARK2 gene, comprising 465 amino acids and containing an N‑terminal ubiquitin‑like domain and C‑terminal RING domains. It plays a pivotal role in the ubiquitin–proteasome system, tagging damaged or misfolded proteins for degradation. Parkin is essential for mitophagy, the selective clearance of dysfunctional mitochondria, thereby maintaining cellular homeostasis. Mutations in PARK2 cause autosomal recessive juvenile Parkinson’s disease, leading to dopaminergic neuron loss. Beyond neuroprotection, Parkin influences apoptosis regulation and cellular stress responses. Its dysfunction is linked to mitochondrial impairment, protein aggregation, and neurodegeneration, making it a key target in Parkinson’s disease research