Human Mesothelin / MSLN (487-598) Protein, His Tag (MALS verified)

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Cat. No. / Size
Price
Qty
MSN-H52H3-100ug
$440.00
MSN-H52H3-1mg (500ug X 2)
$2400.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    MSLN, Mesothelin, MPF

  • Source

    Human Mesothelin (487-598) Protein, His Tag (MSN-H52H3) is expressed from human 293 cells (HEK293). It contains AA Met 487 - Ser 598 (Accession # Q13421-3).

    Predicted N-terminus: Met 487

    Request for sequence
  • Molecular Characterization

    Mesothelin Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 14.3 kDa. The protein migrates as 15-25 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Shipping and Storage

    This product is shipped at ambient temperature.

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Mesothelin SDS-PAGE

    Human Mesothelin (487-598) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    Mesothelin SEC-MALS

    The purity of Human Mesothelin (487-598) Protein, His Tag (Cat. No. MSN-H52H3) is more than 90% and the molecular weight of this protein is around 14-25 kDa verified by SEC-MALS.

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Background

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Recent Advances

 
Drug Development Progress
  • English Name:

    Mesothelin

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    55 Details

  • Highest Development Stage:

    Phase 2 Clinical

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