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Mouse MASP2 (287-685) Protein, His Tag

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MA2-M51H3-100ug
$350.00
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MA2-M51H3-1mg
$2,160.00
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MA2-M51H3
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

MASP2, MASP-2, Mannan-binding lectin serine protease 2, MASP1P1, sMAP

Source

Mouse MASP2 (287-685) Protein, His Tag (MA2-M51H3) is expressed from E. coli cells. It contains AA Thr 287 - Phe 685 (Accession # Q91WP0).

Predicted N-terminus: Met

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 45.4 kDa. The protein migrates as 45-50 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Supplied as 0.2 μm filtered solution in 50 mM Tris, 0.3 M Arginine, 0.5 M NaCl, pH8.0 with glycerol as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 3 months under sterile conditions.
ACRO Quality Management System

Background

Mannan-binding lectin-associated serine protease 2 (MASP-2) is a member of the lectin pathway of complement and is one of two splice products from the MASP2 gene. The protein is secreted from the liver as a zymogenic protein consisting of 671 residues and circulates at a concentration of approximately 0.41 μg/mL in the serum. MASP-2 is associated with pattern-recognition molecules as a homodimer that is activated by MASP-1 when bound to an activating surface resulting in an A-chain and a B-chain linked by a disulphide bond. MASP-2 is also capable of autoactivating. Activated MASP-2 cleaves C2 and C4, which leads to formation of the C3 convertase, C4b2a, and activation of complement.