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Product Details
Synonyms
Integrin alpha V beta 3, ITGAV&ITGB3
Source
Mouse ITGAV&ITGB3 Heterodimer Protein, His Tag&Tag Free (IT3-M52W3) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 988 | Glu 26 - Asp 717 (Accession # P43406-1 | O54890).
Predicted N-terminus: Phe 31 | Glu 26
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
The protein has a calculated MW of 112.5 kDa | 81.6 kDa. The protein migrates as 95-105 kDa, 120-130 kDa and 140-160 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
The protein is designed as a heterodimer.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.
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Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Performance Data
SDS-PAGE
Mouse ITGAV&ITGB3 Heterodimer Protein, His Tag&Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Mouse ITGAV&ITGB3 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT3-M52W3) is more than 90% and the molecular weight of this protein is around 195-240 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Human Vitronectin Protein, Tag Free (Cat. No. VIN-H5214) at 5 μg/mL (100 μL/well) can bind Mouse ITGAV&ITGB3 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT3-M52W3) with a linear range of 0.02-0.313 μg/mL (QC tested).
Protocol
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Background
Recent Advances
Drug Development Progress- English Name：
Integrin alpha-V/beta-3
- Category：
- Approved Drugs：
0 Details
- Drugs in Clinical Trials：
31 Details
- Highest Development Stage：
NDA/BLA
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