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Product Details
Synonyms
Interleukin-22 receptor subunit alpha-1, IL-22 receptor subunit alpha-1, IL-22R-alpha-1, IL-22RA1, Cytokine receptor class-II member 9, Cytokine receptor family 2 member 9, CRF2-9, ZcytoR11, IL22RA1 , IL22R
Source
Cynomolgus IL-22 R alpha 1 Protein, His Tag (IL1-C52H7) is expressed from human 293 cells (HEK293). It contains AA Pro 18 - Thr 225 (Accession # A0A2K5TKX9).
Predicted N-terminus: Pro 18
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 25.6 kDa. The protein migrates as 33-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
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Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Data Display
SDS-PAGE
Cynomolgus IL-22 R alpha 1 Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Cynomolgus IL-22 R alpha 1 Protein, His Tag (Cat. No. IL1-C52H7) is more than 90% and the molecular weight of this protein is around 30-45 kDa verified by SEC-MALS.
Report
Bioactivity-SPR
Cynomolgus IL-22 R alpha 1 Protein, His Tag (Cat. No. IL1-C52H7) immobilized on CM5 Chip can bind Cynomolgus IL-22 Protein, His Tag (Cat. No. IL2-C52H7) with an affinity constant of 58.9 nM as determined in a SPR assay (Biacore 8K) (QC tested).
Protocol
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Background Introduction
Frontier Progress
Drug Development Progress- English Name：
Interleukin-22 receptor
- Category：
- Listed Drugs Count：
0 Details
- Clinical Drugs Count：
5 Details
- Highest R&D Stage：
Phase 2 Clinical
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