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COADS MSDS

Human IL-17 RA&IL-17 RC Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)

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COADS MSDS
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ILC-H5257-100ug
$415.00
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ILC-H5257-1mg (500ug X 2)
$3,005.00
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ILC-H5257
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Product Details
Performance Data
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  • Product Details
  • Performance Data
  • Reviews & Citations
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Synonyms

IL-17 RA & IL-17 RC, IL-17RA & IL-17RC, CD217 & IL-17 RC

Source

Human IL17RA&IL17RC Protein, Fc Tag&Fc Tag (ILC-H5257) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Trp 320 (IL-17RA) & Leu 21 - His 465 (IL-17RC) (Accession # Q96F46-1 (IL-17RA) & NP_703190.1 (IL-17RC)).

Predicted N-terminus: Leu 33 (IL-17RA) & Leu 21 (IL-17RC)

Molecular Characterization

Human IL17RA & IL17RC Protein, Fc Tag&Fc Tag is produced by co-expression of IL-17RA and IL-17RC, has a calculated MW of 60.0 kDa (IL-17RA) & 75.7 kDa (IL-17RC). Subunit IL-17RA is fused with a human IgG1 Fc tag at the C-terminus and subunit IL-17RC is fused with a human IgG1 Fc tag at the C-terminus. The protein migrates as 80-90 kDa and 100-110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to Glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>95% as determined by SDS-PAGE.

>95% as determined by SEC-MALS.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state from date of receipt;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation.