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Human IFN-alpha / beta R2 Protein, Fc Tag

AIDD‑Ready
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IF2-H5255-100ug
$285.00
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IF2-H5255-1mg (500ug X 2)
$2,090.00
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IF2-H5255
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

IFNAR2, IFNARB, IFNABR, IFN-R-2, IFN-alpha, beta receptor 2

Source

Human IFNAR2, Fc Tag (IF2-H5255) is expressed from human 293 cells (HEK293). It contains AA Ile 27 - Lys 243 (Accession # P48551-2).

Predicted N-terminus: Ile 27

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 51.4 kDa. The protein migrates as 64-80 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 1.0 EU per μg by the LAL method / rFC method.

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 12 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System

Background

Interferon alpha/beta receptor 2 (IFR2) is also known as IFN-alpha binding protein, IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFBR and IFRB, which is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. IFR2 can associate with IFR1 to form the type I interferon receptor. IFR2 is a receptor for interferons alpha and beta.IFR2 involves in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 of IFR2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 of IFR2 is a potent inhibitor of type I IFN receptor activity.Genetic variations in IFR2 influence susceptibility to hepatitis B virus (HBV) infection.