Collect Product
Product Details
Synonyms
ERBB2, CD340, HER-2, neu, HER2, MLN19, NEU, NGL, TKR1
Source
Cynomolgus Her2 Protein, Fc Tag (HE2-C5253) is expressed from human 293 cells (HEK293). It contains AA Thr 23 - Thr 652 (Accession # XP_005584091.2).
Predicted N-terminus: Thr 23
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 95.8 kDa. The protein migrates as 120-150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
Formulation
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
ACRO Quality Management System
Kunden haben auch angesehen
Data Display
SDS-PAGE
Cynomolgus Her2 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
Bioactivity-ELISA
Immobilized Cynomolgus Her2 Protein, Fc Tag (Cat. No. HE2-C5253) at 1 μg/mL (100 μL/well) can bind Trastuzumab Biosimilar with a linear range of 0.4-6 ng/mL (QC tested).
Protocol
Immobilized Cynomolgus Her2 Protein, Fc Tag (Cat. No. HE2-C5253) at 1 μg/mL (100 μL/well) can bind Bispecific Antibody (Her2 × Her3) with a linear range of 0.4-6 ng/mL (Routinely tested).
Protocol
Immobilized Cynomolgus Her2 Protein, Fc Tag (Cat. No. HE2-C5253) at 1 μg/mL (100 μL/well) can bind Pertuzumab Biosimilar with a linear range of 2-25 ng/mL (Routinely tested).
Protocol
User Reviews Publish Comment
Background Introduction
Frontier Progress
Drug Development Progress- English Name：
Receptor protein-tyrosine kinase erbB-2
- Category：
- Listed Drugs Count：
47 Details
- Clinical Drugs Count：
238 Details
- Highest R&D Stage：
Approved
Contact Us
Drug Candidate Licensing
