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Human Cyclophilin A / PPIA Protein, Tag Free (MALS verified)

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CYA-H5113-100ug
$367.00
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CYA-H5113-1mg
$2,625.00
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CYA-H5113
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Product Details
Performance Data
Reviews & Citations
Resources
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources
Synonyms

PPIA, Cyclophilin A, Rotamase A, PPIase A, CYPA, CYPH

Source

Human Cyclophilin A Protein, Tag Free (CYA-H5113) is expressed from E. coli cells. It contains AA Met 1 - Glu 165 (Accession # P62937).

Predicted N-terminus: Met 1

Molecular Characterization
Other Tags and Version Biotin & Other Labeled Version

This protein carries no "tag".

The protein has a calculated MW of 18.0 kDa. The protein migrates as 15-17 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

Purity

>90% as determined by SDS-PAGE.

>95% as determined by SEC-MALS.

Formulation

Supplied as 0.2 μm filtered solution in PBS, pH7.4 with glycerol as protectant.

Contact us for customized product form or formulation.

Shipping and Storage

This product is supplied and shipped on dry ice.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • The product MUST be stored at -70°C or lower upon receipt;
  • -70°C for 3 months under sterile conditions.
ACRO Quality Management System

Background

Cyclophilin A (CypA) is a highly abundant intracellular peptidyl-prolyl isomerase. Traditionally targeted by immunosuppressants and antivirals, CypA is now driving a paradigm shift in oncology. In novel "tri-complex" therapies, small molecules bind CypA, leveraging its bulky protein structure to form a neo-interface. This complex acts as a steric shield to effectively lock and inhibit previously "undruggable" targets like active KRAS.