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Product Details
Synonyms
EDSPD2
Source
Cynomolgus Complement C1s Protein, His Tag (COS-C52H3) is expressed from human 293 cells (HEK293). It contains AA Glu 16 - Asp 688 (Accession # A0A2K5VQX9).
Predicted N-terminus: Glu 16
Request for sequenceMolecular Characterization
Other Tags and Version Biotin & Other Labeled Version
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 76.7 kDa. The protein migrates as 80-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
Less than 1.0 EU per μg by the LAL method / rFC method.
Purity
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
Formulation
Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
Reconstitution
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
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Data Display
SDS-PAGE
Cynomolgus Complement C1s Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).
SEC-MALS
The purity of Cynomolgus Complement C1s Protein, His Tag (Cat. No. COS-C52H3) is more than 90% and the molecular weight of this protein is around 90-110 kDa verified by SEC-MALS.
Report
Bioactivity-ELISA
Immobilized Claseprubart at 5 μg/mL (100 μL/well) can bind Cynomolgus Complement C1s Protein, His Tag (Cat. No. COS-C52H3) with a linear range of 0.01-0.156 μg/mL (QC tested).
Protocol
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Background Introduction
Frontier Progress
Drug Development Progress- English Name：
Complement C1s
- Category：
- Listed Drugs Count：
4 Details
- Clinical Drugs Count：
5 Details
- Highest R&D Stage：
Approved
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