Human Cadherin-3 Protein, His Tag, low endotoxin

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Cat. No. / Size
Price
Qty
CA3-H52H3-100ug
$415.00
CA3-H52H3-1mg (250ug X 4)
$2615.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    CDH3, CDHP, Cadherin-3, P-cadherin

  • Source

    Human Cadherin-3, His Tag (CA3-H52H3) is expressed from human 293 cells (HEK293). It contains AA Asp 108 - Gly 654 (Accession # P22223-1).

    Predicted N-terminus: Asp 108

    Request for sequence
  • Molecular Characterization

    Cadherin-3 Structure

    Other Tags and Version Biotin & Other Labeled Version

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 61.9 kDa. The protein migrates as 65-70 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 0.01 EU per μg by the LAL method / rFC method.

  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    Cadherin-3 SDS-PAGE

    Human Cadherin-3, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

  • Bioactivity-ELISA

     Cadherin-3 ELISA

    Immobilized Human Cadherin-3, His Tag (Cat. No. CA3-H52H3) at 5 μg/mL (100 μL/well) can bind Human CDCP1 Protein, Fc Tag (Cat. No. CD1-H5254) with a linear range of 0.078-2.5 μg/mL (QC tested).

    Protocol

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Background

Cadherin-3 (also known as P-cadherin)is a classical cell-to-cell adhesion molecule with a homeostatic function in several normal tissues. In humans, cadherin-3 is only detected in a few organs. However, its overexpression is strongly associated with a poor prognosis in some solid tumors including breast, lung and pancreatic cancers.

Recent Advances

 
Drug Development Progress
  • English Name:

    Cadherin 3

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    7 Details

  • Highest Development Stage:

    Phase 2 Clinical

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