Human BMP-4 / BMP2B Protein, premium grade

GMP version GMP-BM4H36 is now available for seamless transition.
Product Number/Spec
Price
Availability
Menge
Premium grade lyophilized
BM4-H5317-20ug
$335.00
In Stock - Delivery in 1-2 business days
BM4-H5317-50ug
$425.00
In Stock - Delivery in 1-2 business days
BM4-H5317-1mg (200ug X 5)
$3,835.00
In Stock - Delivery in 1-2 business days
GMP lyophilized
GMP-BM4H36-50ug
$870.00
In Stock - Delivery in 1-2 business days
GMP-BM4H36-1mg (50ug X 20)
$8,205.00
GMP-BM4H36-10mg (50ug X 200)
$57,435.00
BM4-H5317
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Features and Advantages
  • Seamless Transition from Preclinical to Clinical: Same cell clone, process, and QC as GMP products.
  • Enhanced Production Standards: AOF raw materials, pharma-grade excipients, Grade B+A (ISO 5) environment.
  • Comprehensive Quality Control: Additional strict testing for process impurities, sterility, and mycoplasma.
  • Cost-Effective Solution: GMP-comparable quality at an economical price for early development.
  • Risk Mitigation: Enhanced safety through rigorous impurity control and comprehensive testing.
Synonyms

BMP4, BMP2B, BMP2B1, MCOPS6, OFC11, ZYME

Source

Human BMP-4 Protein, premium grade (BM4-H5317) is expressed from CHO cells. It contains AA Ser 293 - Arg 408 (Accession # NP_001193.2).

Predicted N-terminus: Ser 293

It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage.
GMP-BM4H36 is the GMP version of this BM4-H5317. These two proteins display indistinguishable performance profiles, thereby ensuring a seamless transition for end users from early preclinical stage to later clinical phases.

Molecular Characterization

This protein carries no "tag".

The protein has a calculated MW of 13.1 kDa. The protein migrates as 21 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Endotoxin

Less than 0.01 EU per μg by the LAL method / rFC method.

Host Cell Protein

<0.5 ng/µg of protein tested by ELISA.

Host Cell DNA

<0.02 ng/μg of protein tested by qPCR.

Sterility

Negative

Mycoplasma

Negative

Purity

>95% as determined by SDS-PAGE.

Formulation

Lyophilized from 0.22 μm filtered solution in 20 mM Citric acid, pH2.2 with trehalose as protectant.

Contact us for customized product form or formulation.

Reconstitution

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

Shipping and Storage

This product is shipped at ambient temperature.

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:
  • -20°C to -70°C for 24 months in lyophilized state;
  • -70°C for 3 months under sterile conditions after reconstitution.
Quality Description

ACRO's Research-grade products are suitable for a wide range of cell culture applications, particularly for research use in academic institutions. These products are sterilized by filtration, followed by lyophilization where applicable. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. Biological activity is calibrated against WHO/NIBSC standards when available.
ACRO's Premium-grade (Pre-GMP) products are characterized by their high quality and enhanced safety profiles, making them ideal for early-stage discovery and manufacturing processes in cell therapy companies. A key advantage is their seamless transition to corresponding GMP-grade versions. Biological activity is calibrated against WHO/NIBSC standards when available. Typical specifications include endotoxin levels of <0.01 EU/μg and purities >95%. In addition, rigorous testing is conducted to ensure the absence of mycoplasma, HCD, and HCP, thereby guaranteeing product safety.

Background Introduction

Bone Morphogenetic Protein 4 (BMP4) is a member of growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. BMP-4 Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. BMP-4 can acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.