Human ACE2 / ACEH Protein, Fc Tag (MALS verified)

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Cat. No. / Size
Price
Qty
AC2-H5255-200ug
$1030.00
AC2-H5255-1mg
$3170.00
AC2-H5255-10mg
$23070.00
AC2-H5255-100mg
$184575.00
ETA of in-stock products:2 business days

Product Details

  • Synonyms

    ACE-2, ACEH, ACE2

  • Source

    Human ACE2, Fc Tag (AC2-H5255) is expressed from human 293 cells (HEK293).

    Request for sequence

  • Molecular Characterization

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 110.0 kDa. The protein migrates as 125-150 kDa under reducing (R) condition, and 250-300 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Supplied as 0.2 μm filtered solution in PBS, pH7.4.

    Contact us for customized product form or formulation.

  • Shipping and Storage

    This product is supplied and shipped on dry ice.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 12 months under sterile conditions.
  • ACRO Quality Management System

    1. QMS(ISO, GMP)
    2. Quality Advantages
    3. Quality Control Process

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Performance Data

  • SDS-PAGE

    ACE2 SDS-PAGE

    Human ACE2, Fc Tag on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

  • SEC-MALS

    ACE2 SEC-MALS

    The purity of Human ACE2, Fc Tag (Cat. No. AC2-H5255) is more than 80% and the molecular weight of this protein is around 240-290 kDa verified by SEC-MALS.

    Report
  • Bioactivity-ELISA

     ACE2 ELISA

    Immobilized Human ACE2, Fc Tag (Cat. No. AC2-H5255) at 2 μg/mL (100 μL/well) can bind Biotinylated SARS-CoV-2 S1 protein, His,Avitag (Cat. No. S1N-C82E8) with a linear range of 40-625 ng/mL (QC tested).

    Protocol

Customer Reviews
Writing Reviews

  • K***k2021-10-08
    Likes
    ACRO biosystem’s protein has been very useful in research and development for our diagnostic assays! They ship very fast and this product has been reliable so far. ACRO biosystem’s sales representative was very professional and helpful to our team! Their website and catalog is very user friendly and easy for any one to use. We always look forward to working with ACRO biosystems and their llamas!

Background

Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.

Recent Advances

 
Drug Development Progress
  • English Name:

    Angiotensin-converting enzyme 2

  • Category:

  • Approved Drugs:

    0 Details

  • Drugs in Clinical Trials:

    7 Details

  • Highest Development Stage:

    Phase 2 Clinical

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