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VCAM-1

VCAM-1 Overview

English Name	Vascular cell adhesion molecule 1	Approved Drugs	2
Drugs in Clinical Trials	1	Target Synonym	VCAM1，Vascular cell adhesion protein 1，V-CAM 1，CD106，Vascular Cell Adhesion Molecule 1，CD106 Antigen，INCAM-100，VCAM-1，Vascular Cell Adhesion Molecule-1
Highest Development Stage	Approved

English Name	Vascular cell adhesion molecule 1
Target Synonym	VCAM1，Vascular cell adhesion protein 1，V-CAM 1，CD106，Vascular Cell Adhesion Molecule 1，CD106 Antigen，INCAM-100，VCAM-1，Vascular Cell Adhesion Molecule-1
Approved Drugs	2
Drugs in Clinical Trials	1
Highest Development Stage	Approved

VCAM-1 Product List

Product Category
Protein (8)Cell Grade Beads (2)
Product Status
Launched (10)
Species
Human (6)- (1)Cynomolgus (2)Mouse (1)
Tag
His Tag (3)Fc Tag (2)Fc Tag & Avi Tag (2)- (2)His Tag & Avi Tag (1)
Conjugate
Unconjugated (5)Biotin-labeled (3)- (2)

Cat. No.	Species	Host	Product Description
HOT GMP-VC1H25	Human	HEK293	GMP Human VCAM-1 Protein, Fc Tag
HOT VC1-H5224	Human	HEK293	Human VCAM-1 / CD106 Protein, His Tag, low endotoxin (MALS verified)
HOT VC1-H5253	Human	HEK293	Human VCAM-1 / CD106 Protein, Fc Tag, premium grade
HOT VC1-H82F6	Human	HEK293	Biotinylated Human VCAM-1 / CD106 Protein, Fc,Avitag™, premium grade
MBS-C019	Human	-	ActiveMax® Human VCAM-1 / CD106 μBeads, premium grade (for cells)
VC1-H83F3	Human	CHO	Biotinylated Human VCAM-1 / CD106 Protein, Fc,Avitag™, premium grade (CHO)
VC1-M52H3	Mouse	HEK293	Mouse VCAM-1 / CD106 Protein, His Tag (MALS verified)
MBS-C028	-	-	ActiveMax® VCAM-1 μBeads, premium grade (for cells, 20 μm)
VC1-C52H3	Cynomolgus	HEK293	Cynomolgus VCAM-1 Protein, His Tag (MALS verified)
VC1-C82E3	Cynomolgus	HEK293	Biotinylated Cynomolgus VCAM-1 / CD106 Protein, His,Avitag™ (MALS verified)

Total: 10

VCAM-1 Background

Vascular cell adhesion protein 1 (VCAM1) is also known as CD106, INCAM-100 and L1CAM, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. VCAM1 / CD106 contains 7 Ig-like C2-type (immunoglobulin-like) domains. CD106 / VCAM-1 is expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue. L1CAM / VCAM-1 is Important in cell-cell recognition and appears to function in leukocyte-endothelial cell adhesion. CD106 / VCAM1 interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1 / VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. INCAM-100 / VCAM1 binds to ECMV-D capsid proteins and acts as a receptor for this virus.

VCAM-1 Synonyms

VCAM1,CD106,INCAM-100,V-CAM 1,VCAM-1

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
99mTc-cAbVCAM1-5	99mTccAbVCAM1‐5; 99mTc-cAbVCAM1-5	Phase 1 Clinical	Medico-Economic Evaluation Unit , University Hospital, Grenoble	Atherosclerosis; Cardiovascular Diseases	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Tocopherol acetate	DSE-9912	Approved	National Institute Of Diabetes And Digestive And Kidney Diseases	Ephynal, Aquasol E	Japan	Vitamin E Deficiency; Diabetic Retinopathy; Atherosclerosis; Intermittent Claudication; Venous Thromboembolism; Thrombosis	Eisai Co Ltd	1951-09-01	Atherosclerosis; Diabetic Retinopathy; Intermittent Claudication; Metabolic Dysfunction-Associated Steatotic Liver Disease; Thrombosis; Venous Thromboembolism; Vitamin E Deficiency	Details
Ascorbic Acid/Biotin/Cholecalciferol/Cyanocobalamin/Dexpanthenol/Folic acid/Niacinamide/Pyridoxine/Riboflavin/Thiamine/Tocopherol Acetate/Vitamin A/Vitamin K		Approved	Sandoz Canada Inc	Infuvite Pediatric	United States	Avitaminosis	Sandoz Canada Inc	2001-02-21	Avitaminosis	Details