TrkB

TrkB Molekülinformation

Englischer Name	Neurotrophic tyrosine kinase receptor type 2	Anzahl der inverkehr gebrachten Arzneimittel	5
Anzahl der klinischen Arzneimittel	13	Target-Alias	EC:2.7.10.1，EC 2.7.10，Tropomyosin-related kinase B，Trk-B，GP145-TrkB，NTRK2，Neurotrophic Receptor Tyrosine Kinase 2，Neurotrophic Tyrosine Kinase Receptor Type 2，TRKB，Neurotrophic Tyrosine Kinase， Receptor， Type 2，BDNF-Tropomyosine Receptor Kinase B，BDNF/NT-3 Growth Factors Receptor，Tyrosine Kinase Receptor B，TrkB Tyrosine Kinase，EC 2.7.10.1，EIEE58，OBHD，Receptor， trkB
Höchste Forschungs- und Entwicklungsphase	Approved

Englischer Name	Neurotrophic tyrosine kinase receptor type 2
Target-Alias	EC:2.7.10.1，EC 2.7.10，Tropomyosin-related kinase B，Trk-B，GP145-TrkB，NTRK2，Neurotrophic Receptor Tyrosine Kinase 2，Neurotrophic Tyrosine Kinase Receptor Type 2，TRKB，Neurotrophic Tyrosine Kinase， Receptor， Type 2，BDNF-Tropomyosine Receptor Kinase B，BDNF/NT-3 Growth Factors Receptor，Tyrosine Kinase Receptor B，TrkB Tyrosine Kinase，EC 2.7.10.1，EIEE58，OBHD，Receptor， trkB
Anzahl der inverkehr gebrachten Arzneimittel	5
Anzahl der klinischen Arzneimittel	13
Höchste Forschungs- und Entwicklungsphase	Approved

TrkB Produktliste

Attribut
Protein (3)Cell (2)
Produktbibliothek
Online (5)
Spezies
Human (5)
Etikett
Fc Tag (1)His Tag (1)Tag Free (1)His Tag & Avi Tag (1)- (1)
Marker
Unconjugated (2)- (2)Biotin-labeled (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
CHEK-ATF289	Human	HEK293	Human TrkB (Luc) HEK293 Reporter Cell	In den Warenkorb legen
CHEK-ATP082	Human	HEK293	HEK293/Human TrkB Stable Cell Line	In den Warenkorb legen
NT2-H5228	Human	HEK293	Human TrkB / NTRK2 Protein, His Tag	In den Warenkorb legen
NT2-H5254	Human	HEK293	Human TrkB / NTRK2 Protein, Fc Tag	In den Warenkorb legen
NT2-H82E3	Human	HEK293	Biotinylated Human TrkB / NTRK2 Protein, His,Avitag™ (MALS verified)	In den Warenkorb legen

Gesamtmenge5

TrkB Molekülhintergrund

This gene encodes a member of the neurotrophic tyrosine receptor kinase(NTRK)family.This kinase is a membrane-bound receptor that upon neurotrophin binding,phosphorylates itself and members of the MAPK pathway.Signalling through this kinase leads to cell differentiation.Mutations in this gene have been associated with obesity and mood disorders.

TrkB Molekülalias

NTRK2,TRKB,GP145-TrkB

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Lestaurtinib	SPM-924; A-154475.0; KT-5555; SP-924; CEP-701	Phase 3 Clinical	Kyowa Hakko Kirin Co Ltd	Bone Marrow Neoplasms; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Neuroblastoma; Polycythemia Vera; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Psoriasis; Thrombocythemia, Essential	Details
Merestinib	5OGS5K699E; LY-2801653	Phase 2 Clinical	Eli Lilly And Company	Biliary Tract Neoplasms; Bone metastases; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Colorectal Neoplasms; Gallbladder Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microsatellite instability-high cancer; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Skin Melanoma; Solid tumours	Details
FCN-011	FCN-011	Phase 2 Clinical		Solid tumours	Details
MT-200605	MT-200605; MT200605	Phase 2 Clinical	Shaanxi Micot Pharmaceutical Technology Co Ltd	Brain Injuries; Ischemic Stroke; Nervous System Diseases; Obesity; Overweight; Stroke	Details
Emzeltrectinib	CT-3417; TQB-3558	Phase 1 Clinical	Beijing Centaurus Biopharma Co Ltd, Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd	Solid tumours	Details
ACD-856	ACD-856	Phase 1 Clinical	Alzecure Pharma Ab	Alzheimer Disease; Cognition Disorders	Details
HG-030	HG-030	Phase 1 Clinical	Hitgen Inc	Solid tumours	Details
FB_-1002	FB_-1002; FB-1002; 4B02-01	Phase 1 Clinical	4b Technologies (Suzhou) Ltd	Amyotrophic Lateral Sclerosis; Depressive Disorder	Details
FB-1001	FB_-1001; FB-1001; FB1001	Phase 1 Clinical	4b Technologies (Suzhou) Ltd	Glaucoma; Glaucoma, Angle-Closure; Optic Nerve Diseases; Optic Neuropathy, Ischemic	Details
1-D-228	1D228; 1-D-228	Phase 1 Clinical	Guangdong Lewwin Pharmaceutical Research Institute Co Ltd, Guangzhou Zhongkelian Pharmaceutical Research Co Ltd	Carcinoma, Non-Small-Cell Lung	Details
BrAD-R13	BrAD-R13; BrADR13	Phase 1 Clinical	Shenzhen Braegen Pharmaceutical Co Ltd	Alzheimer Disease	Details
T-1301	T-1301; DBPR-216; BPR-1J481; BPR1J481	Phase 1 Clinical	Taivex Therapeutics Corp	Lymphoma; Solid tumours	Details
Paltimatrectinib	PBI-200	Phase 1 Clinical	Pyramid Biosciences	Brain Neoplasms; Desmoplastic Small Round Cell Tumor; Solid tumours	Details

Inverkehr gebrachte Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Frühestes Markenname	Frühestes Genehmigungsland	Früheste Indikation	Früheste Genehmigungsgesellschaft	Früheste Genehmigungsdatum	Indikationen	Klinische Studie
Taletrectinib Adipate	DS-6051b; DS-6051a; DS-6051; AB-106; IBI-344	Approved	Daiichi Sankyo Co Ltd	达伯乐, DOVBLERON, IBTROZI	Mainland China	Carcinoma, Non-Small-Cell Lung	AnHeart Therapeutics Co Ltd	2024-12-17	Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Metastatic breast cancer; Neoplasms; Solid tumours	Details
Entrectinib	NMS-E628; RXDX-101; RG-6268	Approved	Nerviano Medical Sciences Srl	Rozlytrek, 罗圣全	Japan	Carcinoma, Non-Small-Cell Lung	Chugai Pharmaceutical Co Ltd	2019-06-18	Brain Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Hepatic Insufficiency; Leukemia, Myeloid, Acute; Lymphoma, Large-Cell, Anaplastic; Lymphoproliferative Disorders; Melanoma; Neoplasms; Neuroendocrine Tumors; Ovarian Neoplasms; Pancreatic Neoplasms; Salivary Gland Neoplasms; Sarcoma; Solid tumours; Thyroid Cancer, Papillary	Details
Larotrectinib sulfate	LOXO-101; ARRY-470; BAY-2757556	Approved	Array Biopharma	Vitrakvi, 维泰凯	United States	Solid tumours	Bayer Healthcare	2018-11-26	Breast Neoplasms; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Ependymoma; Esophageal Neoplasms; Fibrosarcoma; Glioma; Head and Neck Neoplasms; Hematologic Neoplasms; Hepatoblastoma; Histiocytic Sarcoma; Histiocytosis, Langerhans-Cell; Leukemia; Liver Neoplasms; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Medulloblastoma; Melanoma; Multiple Myeloma; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive, Peripheral; Osteosarcoma; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Rhabdoid Tumor; Rhabdomyosarcoma; Sarcoma; Sarcoma, Ewing; Skin Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Thyroid Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Wilms Tumor; Xanthogranuloma, Juvenile	Details
Repotrectinib	TPX-0005; BMS-986472; ZL-2308	Approved	Turning Point Therapeutics Inc	Augtyro, 奥凯乐	United States	Carcinoma, Non-Small-Cell Lung	Bristol-Myers Squibb Company	2023-11-15	Brain metastases; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Hepatic Insufficiency; Lymphoma; Neoplasms; Solid tumours	Details
Cabozantinib S-malate	XL-184; BMS-907351; RO7047650; RO-7047650	Approved	Exelixis Inc	Cometriq, Cabometyx	United States	Thyroid Neoplasms; Carcinoma, Neuroendocrine	Exelixis Inc	2012-11-29	Adenocarcinoma, Clear Cell; Adenocarcinoma, Follicular; Adenoma, Islet Cell; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Astrocytoma; Bile Duct Neoplasms; Bone metastases; Brain metastases; Brain Neoplasms; Breast Neoplasms; Carcinoma, Adenosquamous; Carcinoma, Endometrioid; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Carcinoma, Papillary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Central Nervous System Neoplasms; Cholangiocarcinoma; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Gastroenteropancreatic neuroendocrine tumor; Glioblastoma; Glioma; Gliosarcoma; Hepatic Insufficiency; Hepatoblastoma; HIV Infections; Kidney Neoplasms; Leiomyosarcoma; Leukemia, Myeloid, Acute; Lymphoma; Medullary thyroid cancer (MTC); Melanoma; Meningioma; Multiple Myeloma; Neoplasm Metastasis; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroendocrin	Details