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TRAIL R1

TRAIL R1 Overview

English Name	Tumor necrosis factor receptor superfamily member 10A	Approved Drugs	1
Drugs in Clinical Trials	3	Target Synonym	TRAIL-R1，Tumor necrosis factor receptor superfamily member 10A，DR4，TRAILR1，APO2，TNFRSF10A，TNF Receptor Superfamily Member 10a，Tumor Necrosis Factor Receptor Superfamily， Member 10a，Death Receptor 4，TRAIL Receptor 1，Cytotoxic TRAIL Receptor，CD261 Antigen，TRAILR-1，CD261，TNF-related apoptosis-inducing ligand receptor 1，Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2
Highest Development Stage	Approved

English Name	Tumor necrosis factor receptor superfamily member 10A
Target Synonym	TRAIL-R1，Tumor necrosis factor receptor superfamily member 10A，DR4，TRAILR1，APO2，TNFRSF10A，TNF Receptor Superfamily Member 10a，Tumor Necrosis Factor Receptor Superfamily， Member 10a，Death Receptor 4，TRAIL Receptor 1，Cytotoxic TRAIL Receptor，CD261 Antigen，TRAILR-1，CD261，TNF-related apoptosis-inducing ligand receptor 1，Tumor Necrosis Factor Receptor Superfamily Member 10a Variant 2
Approved Drugs	1
Drugs in Clinical Trials	3
Highest Development Stage	Approved

TRAIL R1 Product List

Product Category
Protein (2)
Product Status
Launched (2)
Species
Human (2)
Tag
His Tag (1)Fc Tag (1)
Conjugate
Unconjugated (2)

Cat. No.	Species	Host	Product Description	Structure	Purity	Feature
TR1-H5228	Human	HEK293	Human TRAIL R1 / DR4 / TNFRSF10A Protein, His Tag
TR1-H5254	Human	HEK293	Human TRAIL R1 / DR4 / TNFRSF10A Protein, Fc Tag

Total: 2

TRAIL R1 Background

Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.

TRAIL R1 Synonyms

TNFRSF10A,TRAIL-R1,CD261,APO2,DR4

Clinical Drug Information

English Name	Research Code	Highest Development Stage	Company	Indication	Clinical Trial
Dulanermin (Shanghai GeBaiDe)		Phase 3 Clinical	Shanghai Gebaide Biotechnology Co Ltd	Carcinoma, Non-Small-Cell Lung	Details
Recombinant human tumor necrosis factor-related apoptosis-inducing ligand (Shenzhen Xinpeng Biotech)		Phase 3 Clinical	Shenzhen Sinobioway Xinpeng Biomedicine Co Ltd	Neoplasms	Details
HLX56	HLX56; HLX-56	Phase 1 Clinical		Solid tumours	Details

Marketed Drug Information

English Name	Research Code	Highest Development Stage	Company	Earliest Brand Name	Earliest Approval Country	Earliest Indication	Earliest Approval Company	Earliest Approval Date	Indication	Clinical Trial
Aponermin		Approved	Beijing Shadong Biotech Co Ltd	沙艾特, Shaite	Mainland China	Multiple Myeloma	Wuhan Hiteck Biological Pharma Co Ltd	2023-11-02	Multiple Myeloma	Details

Product Reviews

1***22019-09-30
0People Like
Human TRAIL R1 / DR4 / TNFRSF10A Protein, Fc Tag
I purchased TNFRSF10A to measure the binding. I tested the purity first. From the results of the SEC (see attachment), you can see the purity is pretty good, 94.8%.