TIGIT

TIGIT

TIGIT Overview

Molecule Name
T cell immunoglobulin and ITIM domains
Synonyms
TIGIT,VSIG9,VSTM3
Drug Development Progress
Drugs in Clinical Trials40
Approved Drugs0
Highest Development StagePhase 3 Clinical
Target Synonym
V-Set And Immunoglobulin Domain Containing 9,Washington University Cell Adhesion Molecule,V-Set And Transmembrane Domain Containing 3,WUCAM,DKFZp667A205,FLJ39873,V-set and immunoglobulin domain-containing protein 9,TIGIT,VSIG9,T Cell Immunoreceptor With Ig And ITIM Domains,V-Set And Transmembrane Domain-Containing Protein 3,VSIG9, VSTM3,VSTM3,T-Cell Immunoreceptor With Ig And ITIM Domains
Background
T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

TIGIT Product List

Species
  • Human(7)
  • Cynomolgus / Rhesus macaque(5)
  • Mouse(4)
  • Canine(1)
  • Rat(1)
Tag
  • His Tag(5)
  • Fc Tag(4)
  • Fc Tag & Avi Tag(3)
  • His Tag & Avi Tag(3)
  • Mouse IgG Fc Tag(2)
  • Mouse IgG Fc Tag & Avi Tag(1)
Host
  • HEK293(18)
Conjugate
  • Unconjugated(10)
  • Biotin-labeled(7)
  • PE Labeled(1)
Grade
  • RUO(18)
Low Endotoxin
  • Yes(3)
  • No(15)
MoleculeCat. No.Product NameSpeciesHostStructurePurityActivitySize&Price
TIGIT
HOTAvitag
TIT-H82E6
Biotinylated Human TIGIT Protein, His,Avitag™, active dimer (recommended for biopanning) (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISA

$360.00

25ug
TIGIT
Human TIGIT Protein, Mouse IgG2a Fc Tag, low endotoxin (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISABLIFlow

$360.00

100ug
TIGIT
HOTAvitag
TIT-H82F1
Biotinylated Human TIGIT Protein, Fc,Avitag™ (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISAFlow

$360.00

25ug
TIGIT
Human TIGIT Protein, Fc Tag, low endotoxin (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISABLIFlow

$415.00

100ug
TIGIT
Human TIGIT Protein, His Tag, active dimer, low endotoxin (MALS verified)
Human
HEK293
MALSSDS-PAGE
ELISASPRBLI

$415.00

100ug
TIGIT
Cynomolgus / Rhesus macaque TIGIT Protein, His Tag (HPLC verified)
Cynomolgus / Rhesus macaque
HEK293
HPLCSDS-PAGE
ELISABLI

$390.00

50ug
TIGIT
Cynomolgus / Rhesus macaque TIGIT Protein, Mouse IgG2a Fc Tag (MALS verified)
Cynomolgus / Rhesus macaque
HEK293
MALSSDS-PAGE
ELISA

$360.00

50ug
TIGIT
Cynomolgus / Rhesus macaque TIGIT Protein, Fc Tag (MALS verified)
Cynomolgus / Rhesus macaque
HEK293
MALSSDS-PAGE
ELISABLI

$360.00

50ug
TIGIT
Canine TIGIT Protein, His Tag (MALS verified)
Canine
HEK293
MALSSDS-PAGE
ELISABLI

$360.00

100ug
TIGIT
Avitag
TIT-C82E3
Biotinylated Cynomolgus / Rhesus macaque TIGIT Protein, His,Avitag™ (MALS verified)
Cynomolgus / Rhesus macaque
HEK293
MALSSDS-PAGE
ELISA

$360.00

25ug
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Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
VibostolimabMK-7684Phase 3 ClinicalMerck Sharp & Dohme Corp
Carcinoma, Non-Small-Cell Lung; Melanoma; Neoplasm Metastasis; Solid tumours
Details
DomvanalimabGS-0154; AB-154Phase 3 ClinicalAbmuno Therapeutics LLC
Adenocarcinoma; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cholangiocarcinoma; Esophageal adenocarcinoma; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Gastrointestinal Neoplasms; Glioblastoma; Liver Neoplasms; Lung Neoplasms; Melanoma; Microsatellite instability-high cancer; Mismatch Repair Deficient Cancer; Pancreatic Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms
Details
TiragolumabMTIG-7192A; RO-7092284; RG6058-11; RG6058-10; RG-6058Phase 3 ClinicalGenentech Inc
Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Medullary; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Chordoma; Colorectal Neoplasms; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gastroesophageal Junction Neoplasms; Glioblastoma; Head and Neck Neoplasms; Liver Neoplasms; Lung Neoplasms; Lymphoma, B-Cell; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Melanoma; Metastatic breast cancer; Microsatellite instability-high cancer; Multiple Myeloma; Neoplasm Metastasis; Neoplasms; Oral Squamous Cell Carcinoma; Rectal Neoplasms; Rhabdoid Tumor; Sarcoma; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Teratoma; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms
Details
Pembrolizumab/VibostolimabMK-7684APhase 3 ClinicalMerck & Co Inc
Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Endometrial Neoplasms; Esophageal Neoplasms; Gallbladder Neoplasms; Hematologic Neoplasms; Lung Neoplasms; Melanoma; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Small Cell Lung Carcinoma; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms
Details
SHS-006(Nanjing Sanhome Pharmaceutical)SHS-006; SH-006; SH006Phase 3 ClinicalNanjing Sanhome Pharmaceutical Co Ltd
Carcinoma, Hepatocellular; Liver Neoplasms; Solid tumours
Details
RilvegostomigAZD-2936Phase 3 ClinicalAstrazeneca Plc
Adenocarcinoma of Lung; Bile Duct Neoplasms; Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Cholangiocarcinoma; Cystadenocarcinoma, Serous; Endometrial Neoplasms; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Melanoma; Ovarian Neoplasms; Solid tumours; Squamous Cell Carcinoma of Head and Neck; Stomach Neoplasms; Triple Negative Breast Neoplasms
Details
BelrestotugEOS-884448; GSK-4428859; GSK-4428859A; EOS-448Phase 3 ClinicalIteos
Carcinoma, Non-Small-Cell Lung; Head and Neck Neoplasms; Lung Neoplasms; Melanoma; Multiple Myeloma; Neoplasms; Solid tumours
Details
HL-301HL-301Phase 3 ClinicalHanmi Pharmaceutical Co Ltd
Acute Bronchitis; Lung Neoplasms; Pulmonary Disease, Chronic Obstructive; Radiation Pneumonitis
Details
OciperlimabWCD-118; BGB-A1217Phase 3 ClinicalBeOne Medicines Ltd
Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Cholangiocarcinoma; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Lymphoma, Large B-Cell, Diffuse; Nasopharyngeal Carcinoma; Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Uterine Cervical Neoplasms
Details
EtigilimabOMP-313M32Phase 2 ClinicalOncomed Pharmaceuticals Inc
Adenocarcinoma, Clear Cell; Fallopian Tube Neoplasms; Neoplasm Metastasis; Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Solid tumours
Details
RenvistobartBMS-986207; ONO-4686Phase 2 ClinicalBristol-Myers Squibb Company
Carcinoma, Non-Small-Cell Lung; Endometrial Neoplasms; Head and Neck Neoplasms; Ovarian Neoplasms; Solid tumours
Details
NilvanstomigZG-005Phase 2 ClinicalGensun Biopharma Inc
Bile Duct Neoplasms; Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Non-Small-Cell Lung; Gastrointestinal Neoplasms; Lymphoma; Nasopharyngeal Carcinoma; Small Cell Lung Carcinoma; Solid tumours; Uterine Cervical Neoplasms
Details
AK-130AK-130Phase 2 Clinical
Bile Duct Neoplasms; Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Neoplasms; Pancreatic Neoplasms; Solid tumours
Details
HB-0036HB-0036Phase 2 ClinicalHuaBo Biopharm Co Ltd
Carcinoma, Non-Small-Cell Lung; Solid tumours
Details
HY-07121HY-07121; HY07121Phase 2 ClinicalSichuan Huiyu Seacross Pharma Technology Ltd
Solid tumours
Details
PM-1022PM-1022Phase 2 Clinical
Neoplasms
Details
LancastotugAK-127Phase 2 Clinical
Carcinoma, Hepatocellular; Neoplasms; Solid tumours
Details
HLX-301HLX-301Phase 2 Clinical
Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Lymphoma; Neoplasm Metastasis; Neoplasms; Small Cell Lung Carcinoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck
Details
HLX-53HLX-53; HLX53Phase 2 Clinical
Carcinoma, Hepatocellular; Lymphoma; Solid tumours
Details
PM-1009PM1009Phase 2 Clinical
Carcinoma, Hepatocellular; Liver Neoplasms; Lung Neoplasms; Neoplasms; Solid tumours
Details
DargistotugM-6223; M6223Phase 2 ClinicalEmd Serono Research & Development Institute Inc
Carcinoma, Transitional Cell; Solid tumours
Details
DW-2008DW-2008; DW-2008SPhase 1 ClinicalDong Wha Pharm Co Ltd
Asthma; Coronavirus Disease 2019 (COVID-19); Rhinitis, Allergic
Details
TamgiblimabIBI-939Phase 1 Clinical
Lung Neoplasms; Neoplasms
Details
COM-902COM-902; CGEN-15137Phase 1 ClinicalCompugen Ltd
Colonic Neoplasms; Colorectal Neoplasms; Lung Neoplasms; Multiple Myeloma; Neoplasms; Neoplasms, Plasma Cell; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck
Details
HY-0007HY-0007Phase 1 ClinicalSichuan Huiyu Pharmaceutical Co Ltd
Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Lung Neoplasms; Melanoma; Ovarian Neoplasms; Small Cell Lung Carcinoma; Solid tumours
Details
SIM-0348SIM-0348Phase 1 ClinicalSimcere Pharmaceutical Group Ltd
Neoplasms; Solid tumours
Details
Recombinant humanized anti-TIGIT monoclonal antibody(Lepu biopharma)LP-010Phase 1 ClinicalLepu Biopharma Co Ltd
Solid tumours
Details
ASP-8374ASP-8374; PTZ-201Phase 1 ClinicalAstellas Pharma Inc, Potenza Therapeutics
Glioblastoma; Solid tumours
Details
BMS-986442AGEN-1777; BMS-986442; BMS-986-442Phase 1 ClinicalAgenus Inc
Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Neoplasms; Solid tumours; Stomach Neoplasms
Details
LNF-1802LNF1802; LNF-1802Phase 1 ClinicalShandong New Time Pharmaceutical Co Ltd
Neoplasms
Details
ZGGS-15ZGGS15; ZGGS-15Phase 1 ClinicalSuzhou Zelgen Biopharmaceuticals Co Ltd
Solid tumours
Details
AUR-106AUR-106Phase 1 ClinicalAurigene Discovery Technologies Ltd
Carcinoma, Non-Small-Cell Lung; Carcinoma, Transitional Cell; Colonic Neoplasms; Esophageal Neoplasms; Kidney Neoplasms; Neoplasms; Stomach Neoplasms
Details
BC008-1ABC008-1APhase 1 ClinicalSichuan Luzhou Buchang Biopharmaceutical Co Ltd
Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Glioblastoma; Glioma; Solid tumours
Details
SHR-2002SHR-2002Phase 1 ClinicalShanghai Hengrui Pharmaceutical Co Ltd, Suzhou Suncadia Biopharmaceuticals Co Ltd
Neoplasms
Details
PM-1021PM1021Phase 1 Clinical
Neoplasms
Details
HH-101HH-101Phase 1 ClinicalHuahui Health Ltd
Solid tumours
Details
HB0030HB-0030Phase 1 ClinicalHuaBo Biopharm Co Ltd, Shanghai Huaota Biopharmaceutical Co Ltd
Solid tumours
Details
BAT-6005BAT-6005Phase 1 ClinicalBio-Thera Solutions Ltd
Solid tumours
Details
IBI-321IBI-321Phase 1 Clinical
Neoplasms; Solid tumours
Details
RalzapastotugAB-308Phase 1 ClinicalArcus Biosciences Inc
Carcinoma, Non-Small-Cell Lung; Esophageal Neoplasms; Gastroesophageal Junction Neoplasms; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Melanoma; Multiple Myeloma; Solid tumours; Stomach Neoplasms; Uterine Cervical Neoplasms
Details
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