Thrombopoietin R

Thrombopoietin R Molekülinformation

Englischer Name	Thrombopoietin receptor	Anzahl der inverkehr gebrachten Arzneimittel	8
Anzahl der klinischen Arzneimittel	11	Target-Alias	CD110 Antigen，THCYT2，C-MPL，CD110，MPLV，Receptors， Thrombopoietin，MPL，TPOR，Myeloproliferative leukemia protein，Myeloproliferative Leukemia Virus Oncogene，Proto-Oncogene C-Mpl，TPO-R，MPL Proto-Oncogene， Thrombopoietin Receptor，Thrombopoietin Receptor，THPOR
Höchste Forschungs- und Entwicklungsphase	Approved

Englischer Name	Thrombopoietin receptor
Target-Alias	CD110 Antigen，THCYT2，C-MPL，CD110，MPLV，Receptors， Thrombopoietin，MPL，TPOR，Myeloproliferative leukemia protein，Myeloproliferative Leukemia Virus Oncogene，Proto-Oncogene C-Mpl，TPO-R，MPL Proto-Oncogene， Thrombopoietin Receptor，Thrombopoietin Receptor，THPOR
Anzahl der inverkehr gebrachten Arzneimittel	8
Anzahl der klinischen Arzneimittel	11
Höchste Forschungs- und Entwicklungsphase	Approved

Thrombopoietin R Produktliste

Attribut
Protein (11)
Produktbibliothek
Online (11)
Spezies
Human (1)Mouse (3)Cynomolgus (2)Rabbit (2)Porcine (2)Rat (1)
Etikett
His Tag (6)His Tag & Avi Tag (5)
Marker
Unconjugated (6)Biotin-labeled (5)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT THR-H52H7	Human	HEK293	Human Thrombopoietin R / TPO R Protein, His Tag, low endotoxin (MALS & SPR verified)	In den Warenkorb legen
THR-M52H3	Mouse	HEK293	Mouse Thrombopoietin R Protein, His Tag, low endotoxin (MALS & SPR verified)	In den Warenkorb legen
THR-M52H4	Mouse	HEK293	Mouse Thrombopoietin R Protein, His Tag, low endotoxin	In den Warenkorb legen
THR-M82E3	Mouse	HEK293	Biotinylated Mouse Thrombopoietin R Protein, His,Avitag™	In den Warenkorb legen
THR-C52H3	Cynomolgus	HEK293	Cynomolgus Thrombopoietin R / TPO R Protein, His Tag (MALS & SPR verified)	In den Warenkorb legen
THR-C82E3	Cynomolgus	HEK293	Biotinylated Cynomolgus Thrombopoietin R Protein, His,Avitag™ (MALS verified)	In den Warenkorb legen
THR-P52H3	Porcine	HEK293	Porcine Thrombopoietin R Protein, His Tag (MALS verified)	In den Warenkorb legen
THR-P82E3	Porcine	HEK293	Biotinylated Porcine Thrombopoietin R Protein, His,Avitag™	In den Warenkorb legen
THR-R52H3	Rabbit	HEK293	Rabbit Thrombopoietin R Protein, His Tag	In den Warenkorb legen
THR-R82E3	Rabbit	HEK293	Biotinylated Rabbit Thrombopoietin R Protein, His,Avitag™	In den Warenkorb legen

Gesamtmenge11

Thrombopoietin R Molekülhintergrund

Thrombopoietin R, also known as TPO-R, is expressed predominantly on the surface of MKs, platelets, hemangioblasts, and hematopoietic stem cells (HSCs). Binding of TPO to the megakaryocyte TPO-R leads to different effects: prevention of megakaryocyte apoptosis; increased megakaryocyte number, size, and ploidy; increasing rate of megakaryocyte maturation; and internalization of the TPO/TPO-R complex. Thrombopoietin R involved in multiple signal transduction pathways, such as JAK, STAT, and MAP kinase.

Thrombopoietin R Molekülalias

MPL,C-MPL,CD110,MPLV,THCYT2,TPOR

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Romiplostim biosimilar (Enzene Biosciences)	267639-76-9	Phase 3 Clinical	Enzene Biosciences Ltd	Purpura, Thrombocytopenic, Idiopathic	Details
Romiplostim biosimilar (Intas Pharmaceuticals)		Phase 3 Clinical	Intas Biopharmaceuticals	Purpura, Thrombocytopenic, Idiopathic	Details
Romiplostim biosimilar(Generium)	GNR-069	Phase 3 Clinical	Cjsc Generium	Purpura, Thrombocytopenic, Idiopathic	Details
PN-20	PN20; PN-20; PJ004; PJ-004	Phase 2 Clinical	Chongqing Peg-Bio Biopharm Co Ltd	Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia	Details
Recombinant human thrombopoietin（Peking University People's Hospital）		Phase 2 Clinical	Peking University People'S Hospital	Parturition; Purpura, Thrombocytopenic, Idiopathic	Details
Recombinant human thrombopoietin mimetics (Shandong Quangang)		Phase 2 Clinical	Shandong Quangang Pharmaceutical Co Ltd	Purpura, Thrombocytopenic, Idiopathic	Details
PEGylated thrombopoietin (Chongqing Paijin Bio)		Phase 2 Clinical	Chongqing Peg-Bio Biopharm Co Ltd	Hematologic Diseases; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia	Details
Romiplostim biosimilar(Geropharma)	GP-40141	Phase 1 Clinical	Geropharm	Purpura, Thrombocytopenic, Idiopathic	Details
SCB-219	SCB-219-M; SCB-219; SCB-219M	Phase 1 Clinical	Clover Biopharmaceuticals Ltd	Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia	Details
Recombinant human thrombopoietin mimetic peptide-Fc fusion protein (Beijing Tide Pharmaceutical)		Phase 1 Clinical	Beijing Tide Pharmaceutical Co Ltd	Purpura, Thrombocytopenic, Idiopathic	Details
Thrombopoietin agonist (Scripps Research)	3D9	Clinical	The Scripps Research Institute Inc	Thrombocytopenia	Details

Inverkehr gebrachte Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Frühestes Markenname	Frühestes Genehmigungsland	Früheste Indikation	Früheste Genehmigungsgesellschaft	Früheste Genehmigungsdatum	Indikationen	Klinische Studie
Recombinant human thrombopoietin biosimilar (Biolotus)		Approved	Biolotus	Zypotin-TPO	Brazil	Thrombocytopenia	Biolotus	2015-01-01	Thrombocytopenia	Details
Romiplostim	AMP-2; AMG-531	Approved	Amgen Inc	Romiplate, Nplate	United States	Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia	Amgen Inc	2008-08-22	Acute Radiation Syndrome; Anemia, Aplastic; Bone Marrow Failure Disorders; Carcinoma, Non-Small-Cell Lung; Hematologic Neoplasms; Hodgkin Disease; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasms; Ovarian Neoplasms; Pancytopenia; Purpura, Thrombocytopenic; Purpura, Thrombocytopenic, Idiopathic; Sarcoma, Ewing; Solid tumours; Thrombocytopenia	Details
Lusutrombopag	S-888711	Approved	Shionogi & Co Ltd	Mulpleta	Japan	Thrombocytopenia	Shionogi & Co Ltd	2015-09-28	Liver Diseases; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia	Details
Herombopag Olamine	SHR-8735; SHR 8735 olamine	Approved	Jiangsu Hengrui Medicine Co Ltd	Hengqu, 恒曲	Mainland China	Anemia, Aplastic; Thrombocytopenia	Jiangsu Hengrui Medicine Co Ltd	2021-06-16	Anemia, Aplastic; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Liver Diseases; Lung Neoplasms; Nasopharyngeal Carcinoma; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia	Details
Romiplostim biosimilar (Qilu Pharmaceutical)	QL-0911	Approved	Qilu Pharmaceutical Co Ltd	瑞立升	Mainland China	Thrombocytopenia	Qilu Pharmaceutical Co Ltd	2024-04-02	Anemia, Aplastic; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia	Details
Eltrombopag Diolamine	SB-497115-GR; ETB-115; SB-497115	Approved	Glaxosmithkline Plc	Promacta/Revolade, 瑞弗兰, レボレード, 特艾升, Promacta, Revolade	United States	Purpura, Thrombocytopenic, Idiopathic	Novartis Pharma Ag	2008-11-20	Anemia, Aplastic; Anemia, Diamond-Blackfan; Blood Platelet Disorders; Bone Marrow Failure Disorders; Bone marrow transplant rejection; Catheter-Related Infections; Delayed Graft Function; Fanconi Anemia; Hematologic Neoplasms; Hematopoietic stem cell transplantation (HSCT); Hemorrhage; Hepatitis B; Hepatitis C; Hepatitis C, Chronic; HIV Infections; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Eosinophilic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myelogenous, Chronic; Leukemia, Myeloid; Leukemia, Myeloid, Accelerated Phase; Leukemia, Myeloid, Acute; Leukemia, Myeloid, Chronic-Phase; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Liver Cirrhosis; Liver Diseases; Metabolic Dysfunction-Associated Steatotic Liver Disease; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasms, Connective and Soft Tissue; Osteosarcoma; Primary Myelofibrosis; Purpura; Purpura, Thrombocytopenic, Id	Details
Avatrombopag Maleate	YM-477; AKR-501; AS-1670542; AKR-501-monomaleate; E-5501	Approved	Astellas Pharma Inc	苏可欣, Doptelet, DOPTELET	United States	Thrombocytopenia; Liver Diseases	Akarx Inc	2018-05-21	Anemia, Aplastic; Cardiovascular Diseases; Drug-Related Side Effects and Adverse Reactions; Liver Diseases; Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia	Details
Recombinant human thrombopoietin	rhTPO (3SBio); TPO106; TPO-106	Approved	Shenyang Sunshine Pharmaceutical Co Ltd	特比奥, Tpiao, 特比澳, Tebiao	Mainland China	Thrombocytopenia; Purpura, Thrombocytopenic, Idiopathic	Shenyang Sunshine Pharmaceutical Co Ltd	2005-03-10	Breast Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Liver Cirrhosis; Liver Diseases; Lymphoma; Multiple Myeloma; Myelodysplastic-Myeloproliferative Diseases; Neutropenia; Plasmacytoma; Purpura, Thrombocytopenic, Idiopathic; Radiation sickness; Sepsis; Thrombocytopenia	Details