TFPI-2

TFPI-2 Molekülinformation

Englischer Name	DNA-(apurinic or apyrimidinic site) lyase	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1	Target-Alias	AP endonuclease 1，DNA-(apurinic or apyrimidinic site) lyase，APE1，APEN，REF-1，Apurinic-apyrimidinic endonuclease 1，APEX nuclease，REF1，APEX，APEX1，Apurinic/Apyrimidinic Endodeoxyribonuclease 1，APEX Nuclease (Multifunctional DNA Repair Enzyme) 1，Redox Factor-1，HAP1，APE，APX，APEX Nuclease (Multifunctional DNA Repair Enzyme)，Deoxyribonuclease (Apurinic Or Apyrimidinic)，Apurinic/Apyrimidinic (Abasic) Endonuclease，AP Endonuclease Class I，Protein REF-1，AP Lyase，APE-1，DNA-(apurinic or apyrimidinic site) endonuclease
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	DNA-(apurinic or apyrimidinic site) lyase
Target-Alias	AP endonuclease 1，DNA-(apurinic or apyrimidinic site) lyase，APE1，APEN，REF-1，Apurinic-apyrimidinic endonuclease 1，APEX nuclease，REF1，APEX，APEX1，Apurinic/Apyrimidinic Endodeoxyribonuclease 1，APEX Nuclease (Multifunctional DNA Repair Enzyme) 1，Redox Factor-1，HAP1，APE，APX，APEX Nuclease (Multifunctional DNA Repair Enzyme)，Deoxyribonuclease (Apurinic Or Apyrimidinic)，Apurinic/Apyrimidinic (Abasic) Endonuclease，AP Endonuclease Class I，Protein REF-1，AP Lyase，APE-1，DNA-(apurinic or apyrimidinic site) endonuclease
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

TFPI-2 Produktliste

Attribut
Protein (1)
Produktbibliothek
Online (1)
Spezies
Human (1)
Etikett
His Tag (1)
Marker
Unconjugated (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
TF2-H5227	Human	HEK293	Human TFPI-2 Protein, His Tag				In den Warenkorb legen

Gesamtmenge1

TFPI-2 Molekülhintergrund

Tissue Factor Pathway Inhibitor 2 (TFPI2) is also known as placental protein 5 (PP5) and retinal pigment epithelial cell factor 1 (REF1), is a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). TFPI2 is highly abundant in the full-term placenta and widely expressed in umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. TFPI2 may play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa and has no effect on thrombin. Reduced synthesis of TFPI-2 has been related to numerous pathophysiological processes such as inflammation, angiogenesis, atherosclerosis, retinal degeneration and tumor growth / metastasis.

TFPI-2 Molekülalias

TFPI2,PP5,REF1

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
APX-3330	APX-3330; APX3330; E-3330	Phase 2 Clinical	Eisai Co Ltd	Solid tumours; Inflammatory Bowel Diseases; Neoplasms; Diabetic macular oedema; Diabetic Retinopathy	Details