Sortilin

Sortilin Molekülinformation

Englischer Name	Sortilin	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	3	Target-Alias	100 kDa NT receptor，NT3，Glycoprotein 95，LDLCQ6，NTR3，Gp95，Sortilin 1，Neurotensin receptor 3
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	Sortilin
Target-Alias	100 kDa NT receptor，NT3，Glycoprotein 95，LDLCQ6，NTR3，Gp95，Sortilin 1，Neurotensin receptor 3
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	3
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Sortilin Produktliste

Attribut
Protein (5)Cell (1)
Produktbibliothek
Online (6)
Spezies
Human (3)Cynomolgus (1)Rat (1)Canine (1)
Etikett
His Tag (4)His Tag & Avi Tag (1)- (1)
Marker
Unconjugated (4)Biotin-labeled (1)- (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
CHEK-ATP155	Human	HEK293	HEK293/Human SORT1 Stable Cell Line	In den Warenkorb legen
SON-H52H5	Human	HEK293	Human Sortilin / SORT1 Protein, His Tag, low endotoxin (MALS verified)	In den Warenkorb legen
SON-H82E9	Human	HEK293	Biotinylated Human Sortilin / SORT1 Protein, His,Avitag™ (MALS & SPR verified)	In den Warenkorb legen
SON-C52H3	Cynomolgus	HEK293	Cynomolgus Sortilin Protein, His Tag	In den Warenkorb legen
SON-C52H4	Canine	HEK293	Canine Sortilin Protein, His Tag	In den Warenkorb legen
SON-R52H3	Rat	HEK293	Rat Sortilin Protein, His Tag (MALS verified)	In den Warenkorb legen

Gesamtmenge6

Sortilin Molekülhintergrund

The Sortilin is a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer.

Sortilin Molekülalias

Sortilin,SORT1,100 kDa NT receptor,Glycoprotein 95,Gp95,Gp95LDLCQ6,Neurotensin receptor 3,NT3NTR3,Ntr3,sortilin 1,

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
VES-001	VES001; VES-001	Phase 2 Clinical	Vesper Bio APS	Dementia; Frontotemporal Dementia; Frontotemporal Lobar Degeneration	Details
Latozinemab	AL-001; GSK-4527223	Phase 1 Clinical	Alector Inc, Glaxosmithkline Plc	Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Neurodegenerative Diseases	Details
ARB-1-6	ARB-1-6; PQ-203	Phase 1 Clinical	ProteinQure Inc	Breast Neoplasms; Solid tumours; Triple Negative Breast Neoplasms	Details