Sonic Hedgehog

Sonic Hedgehog Molekülinformation

Englischer Name	Sonic Hedgehog Homolog	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	4	Target-Alias	HHG-1，Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains，ShhNC，Shh N-terminal processed signaling domains，ShhNp，ShhN，Sonic hedgehog protein，Sonic hedgehog protein N-product，Sonic Hedgehog Signaling Molecule，Sonic Hedgehog (Drosophila) Homolog
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	Sonic Hedgehog Homolog
Target-Alias	HHG-1，Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains，ShhNC，Shh N-terminal processed signaling domains，ShhNp，ShhN，Sonic hedgehog protein，Sonic hedgehog protein N-product，Sonic Hedgehog Signaling Molecule，Sonic Hedgehog (Drosophila) Homolog
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	4
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Sonic Hedgehog Produktliste

Attribut
Protein (4)
Produktbibliothek
Online (4)
Spezies
Human (4)
Etikett
His Tag (1)Tag Free (3)
Marker
Unconjugated (4)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
GMP-SH7H13	Human	E. coli	GMP Human Sonic Hedgehog / Shh (C24II) Protein	In den Warenkorb legen
SH7-H5116	Human	E. coli	Human Sonic Hedgehog / Shh (C24II) Protein, premium grade	In den Warenkorb legen
SH7-H5117	Human	E. coli	Human Sonic Hedgehog / Shh (C24II) Protein, Research Grade	In den Warenkorb legen
SH7-H5229	Human	HEK293	Human Sonic Hedgehog / Shh Protein, His Tag, premium grade	In den Warenkorb legen

Gesamtmenge4

Sonic Hedgehog Molekülhintergrund

Sonic hedgehog protein (SHH) is also known as HHG-1, which belongs to the hedgehog family. SHH is expressed in fetal intestine, liver, lung, and kidney and not expressed in adult tissues. Sonic hedgehog protein can be cleavage into sonic hedgehog protein N-product and sonic hedgehog protein C-product by autolysis. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development. The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.

Sonic Hedgehog Molekülalias

SHH,HHG-1,Sonic hedgehog,HLP3,HPE3,SMMCI,TPT,TPTPS

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
ACC-006	ACC-006	Phase 2 Clinical	China Pharmaceutical University, Jiangsu Aidea Pharmaceutical Group Co Ltd	Carcinoma, Non-Small-Cell Lung; Solid tumours	Details
Sulforafan alfadex	SFX-01; STP-2	Phase 2 Clinical	Evgen Pharma, Lalilab, Pharmagra Labs Inc	Asthma; Autism Spectrum Disorder; Autistic Disorder; Breast Neoplasms; Carcinoma in Situ; Drug-Related Side Effects and Adverse Reactions; Head and Neck Neoplasms; Heart Diseases; Heart Failure, Diastolic; Hyperplasia; Kidney Diseases; Lung Neoplasms; Melanoma; Nasolabial fold wrinkles; Neoplasms; Neurodevelopmental Disorders; Parkinson Disease; Precancerous Conditions; Prostatic Neoplasms; Renal Insufficiency, Chronic; Schizophrenia; Squamous Cell Carcinoma of Head and Neck; Subarachnoid Hemorrhage; Ventricular Dysfunction, Left	Details
NLM-001	NLM-001; TAK-441	Phase 2 Clinical	Millennium Pharmaceuticals Inc	Carcinoma, Basal Cell; Carcinoma, Pancreatic Ductal; Neoplasms	Details
IMP5471-CA		Phase 1 Clinical	Shanghai Impact Pharmaceutical Co Ltd	Hematologic Diseases	Details