SMAC

SMAC Molekülinformation

Englischer Name	Diablo homolog, mitochondrial	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1	Target-Alias	Direct IAP-binding protein with low pI，Second mitochondria-derived activator of caspase，Smac，Diablo IAP-Binding Mitochondrial Protein
Höchste Forschungs- und Entwicklungsphase	Phase 1 Clinical

Englischer Name	Diablo homolog, mitochondrial
Target-Alias	Direct IAP-binding protein with low pI，Second mitochondria-derived activator of caspase，Smac，Diablo IAP-Binding Mitochondrial Protein
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1
Höchste Forschungs- und Entwicklungsphase	Phase 1 Clinical

SMAC Produktliste

Attribut
Protein (1)
Produktbibliothek
Online (1)
Spezies
Human (1)
Etikett
His Tag (1)
Marker
Unconjugated (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
DIO-H5129	Human	E. coli	Human SMAC / Diablo Protein, His Tag				In den Warenkorb legen

Gesamtmenge1

SMAC Molekülhintergrund

Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP),DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.