Siglec-8

Siglec-8 Molekülinformation

Englischer Name	Sialic acid-binding Ig-like lectin 8	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1	Target-Alias	Sialic acid-binding Ig-like lectin 8，SIGLEC8，SAF2，Sialoadhesin family member 2，SAF-2，Sialic Acid Binding Ig Like Lectin 8，Sialic Acid Binding Ig-Like Lectin 8，SIGLEC8L，Siglec-8，MGC59785
Höchste Forschungs- und Entwicklungsphase	Phase 3 Clinical

Englischer Name	Sialic acid-binding Ig-like lectin 8
Target-Alias	Sialic acid-binding Ig-like lectin 8，SIGLEC8，SAF2，Sialoadhesin family member 2，SAF-2，Sialic Acid Binding Ig Like Lectin 8，Sialic Acid Binding Ig-Like Lectin 8，SIGLEC8L，Siglec-8，MGC59785
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1
Höchste Forschungs- und Entwicklungsphase	Phase 3 Clinical

Siglec-8 Produktliste

Attribut
Protein (3)
Produktbibliothek
Online (3)
Spezies
Human (3)
Etikett
His Tag (1)Fc Tag (1)His Tag & Avi Tag (1)
Marker
Unconjugated (2)Biotin-labeled (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Vorbestellen/Bestellen
HOT SI8-H52H8	Human	HEK293	Human Siglec-8 Protein, His Tag, low endotoxin (MALS verified)	In den Warenkorb legen
SI8-H5254	Human	HEK293	Human Siglec-8 Protein, Fc Tag	In den Warenkorb legen
SI8-H82E9	Human	HEK293	Biotinylated Human Siglec-8 Protein, His,Avitag™	In den Warenkorb legen

Gesamtmenge3

Produktanfrage

Siglec-8 Molekülhintergrund

Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8. Siglec-8 was first identified by CD33 homology screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic hypereosinophilic syndrome and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Two splice variants of Siglec-8 exist. The initially characterized form contains 431 amino acid residues in total, subsequently, a longer form of Siglec-8, initially termed Siglec-8L. Both forms of Siglec-8 are found in eosinophils and contain a V-set domain with lectin activity and two C2-type Ig repeat domains in the extracellular region.

Siglec-8 Molekülalias

Siglec-8,SAF-2,SIGLEC8,SAF2

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
AK-001	AK-001	Phase 3 Clinical	Allakos Inc	Community Acquired Pneumonia; Hypersensitivity; Nasal Polyps; Respiratory Tract Infections; Urinary Tract Infections	Details