Semaphorin 4D

Semaphorin 4D Molekülinformation

Englischer Name	Semaphorin 4D	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1	Target-Alias	SEMAJ，SEMA4D，Semaphorin 4D，Sema Domain， Immunoglobulin Domain (Ig)， Transmembrane Domain (TM) And Short Cytoplasmic Domain， (Semaphorin) 4D，C9orf164，CD100，BB18，GR3，A8，Sema Domain， Immunoglobulin Domain (Ig)， Transmembrane Domain (TM) And Short Cytoplasmic Domain， 4D，Chromosome 9 Open Reading Frame 164，CD100 Antigen，M-Sema-G，M-Sema G，Coll-4，COLL4，FLJ39737，Semaphorin-4D
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Englischer Name	Semaphorin 4D
Target-Alias	SEMAJ，SEMA4D，Semaphorin 4D，Sema Domain， Immunoglobulin Domain (Ig)， Transmembrane Domain (TM) And Short Cytoplasmic Domain， (Semaphorin) 4D，C9orf164，CD100，BB18，GR3，A8，Sema Domain， Immunoglobulin Domain (Ig)， Transmembrane Domain (TM) And Short Cytoplasmic Domain， 4D，Chromosome 9 Open Reading Frame 164，CD100 Antigen，M-Sema-G，M-Sema G，Coll-4，COLL4，FLJ39737，Semaphorin-4D
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1
Höchste Forschungs- und Entwicklungsphase	Phase 2 Clinical

Semaphorin 4D Produktliste

Attribut
Protein (1)
Produktbibliothek
Online (1)
Spezies
Human (1)
Etikett
Fc Tag (1)
Marker
Unconjugated (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
CD0-H5257	Human	HEK293	Human Semaphorin 4D / SEMA4D / CD100 Protein, Fc Tag				In den Warenkorb legen

Gesamtmenge1

Semaphorin 4D Molekülhintergrund

Cluster of Differentiation 100 (CD100) is also known as Semaphorin-4D (SEMA4D), is a single-pass type I membrane protein which belongs to the semaphorin family, and is a human 150-kDa homodimer expressed at the surface of most hemopoietic cells. Semaphorin genes encode soluble and membrane-bound proteins, most of which have been shown to act as chemorepellents on growth cone guidance. CD100 is discrete, as it is a transmembrane leukocyte surface molecule that can also exist in a soluble form. Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system. In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still under investigation. It is involved in oligodendrogenesis during development and during recovery from ischemic injury.

Semaphorin 4D Molekülalias

SEMA4D,C9orf164,CD100,FLJ33485,FLJ34282,FLJ39737,FLJ46484,M-sema-G,MGC169138,MGC169141,SEMAJ,coll-4,Semaphorin-4D

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
Pepinemab	VX-15; VX-15/2503; moAb VX-15/2503	Phase 2 Clinical	Vaccinex Inc	Alzheimer Disease; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Colonic Neoplasms; Colorectal Neoplasms; Huntington Disease; Melanoma; Multiple Sclerosis; Osteosarcoma; Pancreatic Neoplasms; Skin Melanoma; Solid tumours; Squamous Cell Carcinoma of Head and Neck	Details