S100B

S100B Molekülinformation

Englischer Name	Protein Nef	Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1	Target-Alias	nef，Negative factor，3'ORF，Protein Nef，F-protein
Höchste Forschungs- und Entwicklungsphase	Phase 1 Clinical

Englischer Name	Protein Nef
Target-Alias	nef，Negative factor，3'ORF，Protein Nef，F-protein
Anzahl der inverkehr gebrachten Arzneimittel	0
Anzahl der klinischen Arzneimittel	1
Höchste Forschungs- und Entwicklungsphase	Phase 1 Clinical

S100B Produktliste

Attribut
Protein (1)
Produktbibliothek
Online (1)
Spezies
Human (1)
Etikett
His Tag (1)
Marker
Unconjugated (1)

Produktnummer	Spezies	Expressionssystem	Produktbeschreibung	Proteinstruktur	Reinheit	Eigenschaften	Vorbestellen/Bestellen
S1B-H5143	Human	E. coli	Human S100B Protein, His Tag				In den Warenkorb legen

Gesamtmenge1

S100B Molekülhintergrund

S-100 protein beta chain (S100B),a member of the S-100 family, is also known as S-100 protein subunit beta and S100 calcium-binding protein B, which contains two EF-hand domains. S100B can weakly bind calcium but bind zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Also, S100B can bind to and initiate the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction,S100B may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Fuethermore,S100B could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. S100B may mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

S100B Molekülalias

S100B,NEF,S100,S100beta

Klinische Arzneimittelinformation

Englischer Name	Forschungscode	Forschungsphase	Firma	Indikationen	Klinische Studie
HIV clade B mRNA dendritic cell therapy (Immunomic Therapeutics/Universite Libre de Bruxelles)		Phase 1 Clinical	Immunomic Therapeutics Inc	HIV Infections	Details