Pleiotrophin Molekülinformation
Molecule Name
Pleiotrophin
Molekülalias
neurite growth-promoting factor 1,HARP,HBBM,HB-GAM,HBGF8,HBNF,HBNF1,HBNF-1,Heparin-binding brain mitogen,HNGF-8,NEGF1HBGF-8,OSF-1,Osteoblast-specific factor 1
Drug Development Progress
Anzahl der klinischen Arzneimittel0
Anzahl der inverkehr gebrachten Arzneimittel0
Höchste Forschungs- und EntwicklungsphasePreclinical
Target-Alias
HBNF，HBGF8，NEGF1，Heparin-Binding Neurite Outgrowth-Promoting Factor 1，Heparin-Binding Growth-Associated Molecule，Heparin-Binding Growth Factor 8，Heparin-Binding Brain Mitogen，Osteoblast-Specific Factor 1，HB-GAM，HBGF-8，HBNF-1，OSF-1，HBBM，Pleiotrophin (Heparin Binding Growth Factor 8， Neurite Growth-Promoting Factor 1)，Heparin-Binding Neurite Outgrowth Promoting Factor，Heparin-Binding Neurite Outgrowth-Promoting Factor，Neurite Growth-Promoting Factor 1，Heparin Affin Regulatory Protein，Heparin Binding Growth Factor 8，HBNF1，HARP
Molekülhintergrund
Pleiotrophin and Midkine are structurally related heparin-binding neurotrophic factors, whose expression is developmentally regulated. The expression pattern of these neurotrophic factors suggests function in neurogenesis, cell migration, secondary organogenetic induction, and mesoderm epithelial interaction. The expression of PTN increases during the process of brain embryogenesis, and reaches maximum levels at time of birth. The physiological roles of PTN and Midkine are largely unknown, but these neurotrophins have been implicated in the pathogenesis of neuroblastomas. Recombinant Human Pleiotrophin is a 15.4 kDa protein containing 136 amino acid residues and five intra-molecular disulfide bonds.
Pleiotrophin Produktliste
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